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Table 2 The 16-week change in inflammatory and oxidative stress markers and anthropometric measures after the DASH diet and legume-based DASH diet according to TCF7L2 rs7903146 gene variant

From: The effect of TCF7L2 polymorphisms on inflammatory markers after 16 weeks of legume-based dietary approach to stop hypertension (DASH) diet versus a standard DASH diet: a randomised controlled trial

 

Total population

 

CC genotype

CT + TT genotype

 
 

DASH diet

Legume-based DASH diet

P value

q value

DASH diet

Legume-based DASH diet

P value

q value

DASH diet

Legume-based DASH diet

P value

q value

P i

Primary outcome

 

hsCRP (mg/dl)

             

Model 1

− 0.57

(− 0.76 to − 0.38)

− 1.22

(− 1.40 to − 1.02)

 < 0.001

 

− 0.51

(− 0.87 to − 0.15)

− 1.08

(− 1.27 to − 0.88)

0.001

 

− 0.65

(− 0.95 to − 0.34)

− 1.33

(− 1.53 to − 1.14)

0.002

 

0.421

Model 2

− 0.58

(− 0.78 to − 0.39)

− 1.20

(− 1.39 to − 1.01)

 < 0001

 

− 0.51

(− 0.87 to − 0.15)

− 1.08

(− 1.28 to − 0.88)

0.002

 

− 0.65

(− 0.95 to − 0.35)

− 1.34

(− 1.52 to − 1.15)

0.002

 

0.237

Secondary outcomes

 

MDA (µM)

             

Model 1

− 1.03

(− 1.28 to − 0.78)

− 1.64

(− 1.88 to − 1.38)

 < 0.001

0.016

− 0.91

(− 1.24 to − 0.58)

− 1.58

(− 1.97 to − 1.18)

0.016

0.040

− 1.11

(− 1.43 to − 0.81)

− 1.73

(− 2.11 to − 1.35)

0.021

0.040

0.455

Model 2

− 1.02

(− 1.27 to − 0.77)

− 1.64

(− 1.89 to − 1.39)

 < 0.001

0.016

− 0.91

(− 1.24 to − 0.58)

− 1.58

(− 1.97 to − 1.18)

0.016

0.040

− 1.11

(− 1.43 to − 0.80)

− 1.73

(− 2.11 to − 1.35)

0.023

0.040

0.573

TNF− α (pg/ml)

             

Model 1

− 0.76

(− 1.23 to − 0.29)

− 2.04

(− 2.51 to − 1.57)

 < 0.001

0.016

− 0.68

(− 1.28 to − 0.08)

− 1.78

(− 2.41 to − 1.16)

0.010

0.038

− 0.87

(− 1.63 to − 0.11)

− 2.27

(− 2.97 to − 1.58)

0.006

0.032

0.593

Model 2

− 0.77

(− 1.24 to − 0.29)

− 2.04

(− 2.51 to − 1.56)

 < 0.001

0.016

− 0.68

(− 1.45 to − 0.08)

− 1.78

(− 2.42 to − 1.14)

0.010

0.038

− 0.87

(− 1.60 to − 0.14)

− 2.28

(− 2.98 to − 1.57)

0.012

0.038

0.496

IL− 6 (pg/ml)

             

Model 1

− 0.53

(− 0.70 to − 0.36)

− 0.93

(− 1.10 to − 0.76)

0.001

0.016

− 0.52

(− 0.68 to − 0.36)

− 0.82

(− 1.05 to − 0.58)

0.028

0.044

− 0.52

(− 0.82 to − 0.22)

− 1.06

(− 1.28 to − 0.85)

0.019

0.041

0.753

Model 2

− 0.51

(− 0.68 to − 0.34)

− 0.95

(− 1.12 to − 0.78)

0.004

0.032

− 0.52

(− 0.68 to − 0.36)

− 0.81

(− 1.04 to − 0.58)

0.012

0.038

− 0.52

(− 0.82 to − 0.22)

− 1.06

(− 1.28 to − 0.85)

0.019

0.040

0.793

BMI (kg/m2)

             

Model 1

− 1.48

(− 1.60 to − 1.36)

− 1.57

(− 1.69 to − 1.45)

0.287

0.382

− 1.41

(− 1.59 to − 1.23)

− 1.56

(− 1.73 to − 1.39)

0.238

0.346

− 1.54

(− 1.67 to − 1.42)

− 1.58

(− 1.79 to − 1.37)

0.709

0.756

0.617

Model 2

− 1.49

(− 1.61 to − 1.37)

− 1.56

(− 1.68 to − 1.44)

0.424

0.492

− 1.41

(− 1.59 to − 1.23)

− 1.56

(− 1.73 to − 1.39)

0.431

0.492

− 1.54

(− 1.67 to − 1.42)

− 1.58

(− 1.79 to − 1.37)

0.859

0.859

0.859

  1. DASH, dietary approach to stop hypertension; FPG, fasting plasma glucose; WC, waist circumference; HOMA-IR, homeostatic model assessment for insulin resistance; Pi, P for interaction between TCF7L2 rs7903146 gene variant and intervention diets
  2. Data for change in primary and secondary outcomes are express as mean (95% confidence interval)
  3. Model 1 adjusted for baseline values
  4. Model 2 adjusted for baseline values and oral anti-diabetic medications
  5. P values were calculated by ANCOVA
  6. q value were calculated by Benjamini–Hochberg correction and Q < 0.2 is significant
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Nutrition & Metabolism

ISSN: 1743-7075

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