High-fat diets containing different types of fatty acids modulate gut-brain axis in obese mice

Hua, Yinan; Shen, Jingyi; Fan, Rong; Xiao, Rong; Ma, Weiwei

doi:10.1186/s12986-022-00675-3

Nutrition & Metabolism

Table 1 Effect of diets on the lipid profiles of plasma

From: High-fat diets containing different types of fatty acids modulate gut-brain axis in obese mice

Fatty acid (mg/ml)	CON	LCSFA	MCSFA	n-3 PUFA	n-6 PUFA	MUFA	TFA	F	P
C8:0	0.000 ± 0.000	0.008 ± 0.015	0.000 ± 0.000	0.000 ± 0.000	0.000 ± 0.000	0.008 ± 0.021	0.000 ± 0.000	1.162	0.342
C12:0	0.000 ± 0.000	0.008 ± 0.022	0.031 ± 0.008^a	0.000 ± 0.000^c	0.002 ± 0.005^c	0.000 ± 0.000^c	0.003 ± 0.007^c	11.883	< 0.001
C13:0	0.000 ± 0.000	0.000 ± 0.000	0.000 ± 0.000	0.000 ± 0.000	0.000 ± 0.000	0.000 ± 0.000	0.007 ± 0.018	1.000	0.436
C14:0	0.005 ± 0.004	0.002 ± 0.003	0.043 ± 0.008^ab	0.002 ± 0.002^c	0.005 ± 0.009^c	0.003 ± 0.003^c	0.003 ± 0.003^c	63.585	< 0.001
C15:0	0.000 ± 0.000	0.000 ± 0.000	0.001 ± 0.001	0.000 ± 0.000	0.000 ± 0.000	0.000 ± 0.000	0.000 ± 0.000	1.750	0.129
C16:0	0.692 ± 0.082	0.668 ± 0.127	0.751 ± 0.063	0.507 ± 0.089^abc	0.613 ± 0.087^c	0.691 ± 0.126^d	0.648 ± 0.155^d	4.060	0.002
C17:0	0.001 ± 0.001	0.003 ± 0.003	0.000 ± 0.000	0.001 ± 0.002	0.001 ± 0.003	0.001 ± 0.002	0.001 ± 0.002	1.232	0.306
C18:0	0.408 ± 0.056	0.433 ± 0.123	0.406 ± 0.021	0.369 ± 0.061	0.413 ± 0.084	0.406 ± 0.094	0.381 ± 0.093	0.522	0.789
C20:0	0.000 ± 0.000	0.000 ± 0.000	0.001 ± 0.001	0.000 ± 0.000	0.000 ± 0.000	0.000 ± 0.000	0.000 ± 0.000	1.000	0.436
C22:0	0.101 ± 0.032	0.000 ± 0.000^a	0.120 ± 0.041^b	0.000 ± 0.000^ac	0.000 ± 0.000^ac	0.028 ± 0.014^abcde	0.002 ± 0.006^acf	51.476	< 0.001
Total SFA	1.207 ± 0.123	1.121 ± 0.245	1.352 ± 0.107^b	0.879 ± 0.144^abc	1.033 ± 0.168^c	1.136 ± 0.227^cd	1.044 ± 0.243^c	5.016	< 0.001
C14:1	0.000 ± 0.000	0.003 ± 0.007	0.001 ± 0.002	0.000 ± 0.000	0.000 ± 0.000	0.000 ± 0.000	0.000 ± 0.000	1.021	0.423
C15:1	0.000 ± 0.000	0.001 ± 0.003	0.000 ± 0.000	0.000 ± 0.000	0.000 ± 0.000	0.000 ± 0.000	0.000 ± 0.000	1.000	0.436
C16:1	0.090 ± 0.019	0.038 ± 0.012^a	0.183 ± 0.037^ab	0.020 ± 0.008^ac	0.021 ± 0.006^ac	0.039 ± 0.008^acde	0.052 ± 0.013^acde	85.237	< 0.001
C17:1	0.000 ± 0.000	0.001 ± 0.003	0.003 ± 0.006	0.004 ± 0.006	0.000 ± 0.000	0.003 ± 0.006	0.000 ± 0.000	1.512	0.194
C18:1 n-9c	0.389 ± 0.050	0.264 ± 0.066^a	0.467 ± 0.090^ab	0.155 ± 0.029^abc	0.163 ± 0.037^abc	0.538 ± 0.072^abcde	0.360 ± 0.051^bcdef	47.979	< 0.001
C20:1	0.000 ± 0.000	0.000 ± 0.000	0.004 ± 0.004	0.000 ± 0.000	0.001 ± 0.002	0.003 ± 0.005	0.000 ± 0.000	3.239	0.009
Total MUFA	0.479 ± 0.064	0.306 ± 0.081^a	0.658 ± 0.124^ab	0.179 ± 0.038^abc	0.185 ± 0.043^abc	0.582 ± 0.086^abde	0.411 ± 0.063^bcdef	48.109	< 0.001
C18:2 n-6c	0.188 ± 0.032	0.377 ± 0.088^a	0.278 ± 0.060^ab	0.516 ± 0.077^abc	0.671 ± 0.121^abcd	0.322 ± 0.077^ade	0.411 ± 0.042^acdef	35.158	< 0.001
C18:3 n-6	0.000 ± 0.000	0.001 ± 0.002	0.002 ± 0.003	0.000 ± 0.000	0.000 ± 0.000	0.000 ± 0.000	0.000 ± 0.000	2.423	0.040
C20:3 n-6	0.037 ± 0.019	0.037 ± 0.017	0.055 ± 0.019	0.010 ± 0.012^abc	0.027 ± 0.018^c	0.053 ± 0.026^de	0.036 ± 0.018^d	5.361	< 0.001
C20:4 n-6	0.433 ± 0.104	0.655 ± 0.168^a	0.498 ± 0.196	0.128 ± 0.043^abc	0.584 ± 0.101^d	0.687 ± 0.189^acd	0.686 ± 0.215^acd	13.006	< 0.001
Total n-6 PUFA	0.658 ± 0.107	1.069 ± 0.234^a	0.833 ± 0.232^b	0.654 ± 0.101^b	1.281 ± 0.218^acd	1.063 ± 0.265^acde	1.133 ± 0.253^acd	10.637	< 0.001
C18:3 n-3	0.000 ± 0.000	0.000 ± 0.000	0.001 ± 0.003	0.098 ± 0.028^abc	0.003 ± 0.006^d	0.000 ± 0.000^d	0.000 ± 0.000^d	89.771	< 0.001
C20:5 n-3	0.000 ± 0.000	0.000 ± 0.000	0.000 ± 0.000	0.198 ± 0.042^abc	0.011 ± 0.009^d	0.009 ± 0.006^abcd	0.000 ± 0.000^df	165.265	< 0.001
C22:6 n-3	0.107 ± 0.029	0.158 ± 0.059	0.102 ± 0.035	0.163 ± 0.025^ac	0.240 ± 0.077^ac	0.244 ± 0.035^acd	0.209 ± 0.050^ac	12.010	< 0.001
Total n-3 PUFA	0.107 ± 0.029	0.158 ± 0.059	0.103 ± 0.035	0.459 ± 0.065^abc	0.254 ± 0.083^abcd	0.253 ± 0.038^abcd	0.209 ± 0.050^acd	40.425	< 0.001
n-6/n-3 PUFA	6.604 ± 2.113	7.447 ± 2.196	8.430 ± 1.454	1.444 ± 0.247^abc	5.510 ± 1.784^d	4.173 ± 0.769^cd	5.582 ± 1.193^cd	17.787	< 0.001
Total PUFA	0.765 ± 0.121	1.227 ± 0.281^a	0.936 ± 0.264^b	1.113 ± 0.143^a	1.534 ± 0.295^abcd	1.316 ± 0.293^ac	1.342 ± 0.283^ac	8.748	< 0.001
C18:1n9t	0.000 ± 0.000	0.000 ± 0.000	0.000 ± 0.000	0.000 ± 0.000	0.000 ± 0.000	0.000 ± 0.000	0.068 ± 0.034^abcdef	31.490	< 0.001

Results expressed as mean ± SD, n = 8 per group; the significance of bold meant P < 0.05
^aP < 0.05, compared to CON group
^bP < 0.05, compared to LCSFA group
^cP < 0.05, compared to MCSFA group
^dP < 0.05, compared to n-3 PUFA group
^eP < 0.05, compared to n-6 PUFA group
^fP < 0.05, compared to MUFA group

Back to article page

ISSN: 1743-7075

Contact us

General enquiries: journalsubmissions@springernature.com