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Table 3 Subgroup analyses for risk of all-cause mortality (adjusted HR [95% CI]) according to baseline HbA1c

From: Association between haemoglobin A1c and all-cause and cause-specific mortality in middle-aged and older Koreans: a prospective cohort study

 

No. of

Deaths, n (%)

HbA1c in participants without known diabetes

Known diabetes

(n = 604)

p-interaction

< 5.0%

5.0–5.4%

5.5–5.9%

6.0–6.4%

≥ 6.5%

(n = 303)

(n = 2962)

(n = 3930)

(n = 1038)

(n = 457)

All-cause death

9294

944 (10.2)

28

228

337

139

69

143

 

 40–49 years

4497

154 (3.4)

1.37 (0.62–3.04)

1.21 (0.84–1.74)

Ref

1.99 (1.20–3.31)

0.69 (0.21–2.21)

1.30 (0.59–2.86)

0.146

 50–69 years

4797

790 (16.5)

1.92 (1.23–3.00)

1.19 (0.98–1.44)

Ref

1.46 (1.17–1.81)

1.73 (1.32–2.27)

2.43 (1.96–3.00)

 

 Men

4458

603 (13.5)

1.72 (1.07–2.77)

1.20 (0.98–1.48)

Ref

1.64 (1.28–2.11)

1.72 (1.22–2.43)

2.10 (1.62–2.73)

0.424

 Women

4836

341 (7.1)

1.76 (0.89–3.49)

1.18 (0.87–1.58)

Ref

1.28 (0.92–1.78)

1.49 (0.99–2.25)

2.71 (1.97–3.73)

 

 Never smoker

5450

414 (7.6)

1.89 (1.09–3.29)

1.19 (0.91–1.55)

Ref

1.31 (0.95–1.80)

1.87 (1.29–2.70)

2.88 (2.16–3.85)

0.042

 Ever smoker

3844

530 (13.8)

1.52 (0.88–2.62)

1.19 (0.96–1.49)

Ref

1.67 (1.29–2.17)

1.45 (0.99–2.12)

1.84 (1.38–2.44)

 

 Hypertension

2939

429 (14.6)

1.63 (0.88–3.03)

1.25 (0.96–1.65)

Ref

1.49 (1.11–2.00)

1.53 (1.07–2.21)

2.25 (1.70–2.96)

0.967

 No hypertension

6355

515 (8.1)

1.79 (1.09–2.96)

1.19 (0.95–1.48)

Ref

1.52 (1.16–2.00)

1.78 (1.22–2.62)

2.39 (1.77–3.21)

 

 Liver disease

411

65 (15.8)

4.12 (1.51–11.23)

1.73 (0.88–3.40)

Ref

2.51 (1.09–5.76)

2.41 (0.52–11.22)

1.41 (0.63–3.15)

0.036

 No liver disease

8883

879 (9.9)

1.43 (0.92–2.24)

1.17 (0.98–1.39)

Ref

1.45 (1.18–1.78)

1.62 (1.24–2.12)

2.34 (1.90–2.88)

 

 Low RBC

4625

580 (12.5)

2.23 (1.48–3.37)

1.19 (0.97–1.47)

Ref

1.43 (1.10–1.86)

1.40 (0.97–2.04)

2.33 (1.78–3.04)

0.172

 High RBC

4669

364 (7.8)

0.42 (0.10–1.72)

1.21 (0.91–1.62)

Ref

1.56 (1.15–2.12)

1.87 (1.28–2.74)

2.21 (1.62–3.01)

 
  1. When not stratified by one of the following, models were adjusted for age (years), sex, residential area (Ansung or Ansan), body mass index (kg/m2), smoking (current, past, or never), alcohol use (current, past, or never), regular exercise (yes or no), education (above or below university), hypertension (yes or no), and dyslipidaemia (yes or no)
  2. Known diabetes was defined as a history of physician-diagnosed diabetes or under treatment with oral antidiabetic agents or insulin
  3. Low or high RBC was classified based on the median (4.72 Mil/µL for men and 4.15 Mil/µL for women)
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Nutrition & Metabolism

ISSN: 1743-7075

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