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Table 6 Verification of the significant interactions between maternal DHA-rich n-3 PUFAs supplementation and genotype of 26 SNPs on the profiles of PUFAs

From: Maternal DHA-rich n-3 PUFAs supplementation interacts with FADS genotypes to influence the profiles of PUFAs in the colostrum among Chinese Han population: a birth cohort study

Gene

SNPs

High DHA-rich n-3 PUFAs intake group (n = 369)*

Low DHA-rich n-3 PUFAs intake group (n = 681)#

b (SE)

t

P

b (SE)

t

P

n-6 PUFAs

 LA

 Fads1

rs174448

1.807 (1.484)

1.218

0.229

1.045 (1.029)

1.016

0.313

 Fads1

rs174553

0.626 (1.365)

0.459

0.649

0.237 (0.857)

0.277

0.782

 Fads2

rs174598

 − 0.522 (1.324)

 − 0.394

0.695

 − 0.076 (0.807)

 − 0.094

0.926

 Fads3

rs174464

1.488 (1.270)

1.171

0.247

 − 0.255 (0.897)

 − 0.285

0.777

 Fads3

rs76996928

 − 1.251 (1.228)

 − 1.019

0.313

 − 1.759 (0.763)

 − 2.305

0.024

 AA

 Fads2

rs174609

0.009 (0.045)

0.209

0.835

0.070 (0.045)

1.557

0.123

n-3 PUFAs

 ALA

 Elovl5

rs209512

 − 0.019 (0.015)

 − 1.237

0.222

 − 0.013(0.010)

 − 1.363

0.178

 EPA

 Fads1

rs174448

0.052 (0.075)

0.695

0.491

0.111 (0.069)

1.611

0.111

 Fads2

rs174598

 − 0.139 (0.055)

 − 2.507

0.016

 − 0.104 (0.047)

 − 1.197

0.072

 DHA

 Fads1

rs174448

 − 0.040 (0.041)

 − 2.171

0.037

0.020 (0.037)

0.545

0.588

 Fads2

rs174598

 − 0.033 (0.033)

 − 0.989

0.328

0.022 (0.030)

0.737

0.464

 Fads2

rs174602

 − 0.012 (0.036)

 − 0.324

0.747

 − 0.058 (0.032)

 − 1.820

0.075

 EPA/ALA

 Elovl5

rs209512

0.542 (0.426)

1.270

0.210

0.232 (0.282)

0.823

0.414

 DHA/ALA

 Fads1

rs174448

0.052 (0.198)

0.263

0.793

0.038 (0.232)

0.165

0.869

 Fads2

rs174619

0.130 (0.194)

0.672

0.505

0.359 (0.203)

1.767

0.082

 DHA/EPA

 Fads1

rs174448

 − 0.145 (0.059)

 − 2.512

0.015

 − 0.026 (0.050)

 − 0.513

0.609

n-6/n-3Σ PUFAs

 Fads1

rs174553

 − 0.264 (1.200)

 − 0.220

0.827

0.070 (1.054)

0.067

0.947

 Fads2

rs174598

0.537 (1.161)

0.463

0.645

0.241 (0.993)

0.243

0.809

 Fads3

rs174464

0.821 (1.130)

0.726

0.471

0.155 (1.102)

0.141

0.888

 Fads3

rs76996928

 − 0.903 (1.077)

 − 0.838

0.406

 − 1.289 (0.942)

 − 1.368

0.175

  1. Fads Fatty acid desaturases, Elovl Elongase of long chain fatty acid, PUFAs Polyunsaturated fatty acids, SNPs Single nucleotide polymorphisms, LA Linoleic acid, AA Arachidonic acid, ALA α-Linolenic acid, EPA Eicosapentaenoic acid, DHA Docosahexaenoic acid
  2. *High DHA-rich n-3 PUFAs intake group was included maternal exogenous DHA-rich n-3 PUFAs supplementation at the early (S1) and middle (S2) pregnancy
  3. #Low DHA-rich n-3 PUFAs intake group was included maternal exogenous DHA-rich n-3 PUFAs supplementation at the late pregnancy (S3) and non-exogenous DHA-rich n-3 PUFAs supplementation during the whole pregnancy
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Nutrition & Metabolism

ISSN: 1743-7075

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