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Fig. 4 | Nutrition & Metabolism

Fig. 4

From: Vascular lipidomics analysis reveales increased levels of phosphocholine and lysophosphocholine in atherosclerotic mice

Fig. 4

Analysis of lipidomic profiling and identification of differential lipids. A Differentially expressed lipids were identified (VIP > 1, P < 0.05). B Heatmap of the levels differentially expressed lipids. Increased levels are indicated in red, and decreased levels are indicated in blue. C Volcano plots of the levels of differentially expressed lipids. Red indicates increased levels, blue indicates decreased levels, and gray indicates no statistical significance. D Z score analysis of the top 20 lipids with large differences ranked by VIP. E Correlation analysis of the top 20 lipids. Red indicates a positive correlation, blue indicates a negative correlation. The larger the dot is, the larger the correlation coefficient between the two variables. F The correlation network diagram of the top 20 lipids (P < 0.05, correlation > 0.95). All data are presented as the means ± SEMs. *P < 0.05, **P < 0.01 and ***P < 0.001 versus the ND group. TG, triglyceride; PE, phosphatidylethanolamine; PC, phosphatidylcholine; PS, phosphatidylserine; PA, phosphatidic acid; SM, sphingomyelin; LPE, lysophosphatidylethanolamine; VIP, variable important in projection; ND, normal diet; HFD, high-fat diet

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Nutrition & Metabolism

ISSN: 1743-7075

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