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Table 3 Adjusted ORs (95% CI) of metabolic regression with repeated-measured metabolic risk factors among baseline MUHS group

From: Risk of subclinical atherosclerosis across metabolic transition in individuals with or without fatty liver disease: a prospective cohort study

 

Age- and sex- adjusted

Multivariable-adjusted†

OR (95% CI)

P value

OR (95% CI)

P value

Waist circumference, cm

0.92 (0.90–0.95)

 < 0.0001

0.91 (0.86–0.97)

0.0015

SBP, mmHg

0.95 (0.93–0.97)

 < 0.0001

0.95 (0.92–0.98)

0.0012

DBP, mmHg

0.95 (0.92–0.97)

 < 0.0001

0.998 (0.95–1.05)

0.9285

Triglycerides, mg/dL

0.49 (0.31–0.75)

0.0013

0.47 (0.23–0.96)

0.0393

HDL-C, mg/dL

6.08 (2.86–12.94)

 < 0.0001

3.72 (1.13–12.28)

0.0307

FPG, mg/dL

0.42 (0.29–0.62)

 < 0.0001

0.51 (0.33–0.79)

0.0022

2 h-PG, mg/dL

0.75 (0.71–0.78)

 < 0.0001

0.79 (0.70–0.89)

 < 0.0001

HbA1c, %

0.13 (0.07–0.23)

 < 0.0001

0.21 (0.08–0.55)

0.0015

HOMA-IR

0.49 (0.38–0.64)

 < 0.0001

0.77 (0.54–1.10)

0.1545

BMI, kg/m2

0.78 (0.70–0.87)

 < 0.0001

0.97 (0.80–1.17)

0.7637

  1. SBP systolic blood pressure; DBP diastolic blood pressure; HDL-C high density lipoprotein cholesterol; FPG fasting plasma glucose; HbA1c glycated hemoglobin; HOMA-IR homeostasis model assessment of insulin resistance; BMI body mass index; MUHS metabolic unhealthy and hepatic steatosis; OR odds ratio; CI confidence interval
  2. †Logistic regression models with generalized estimating equations were adjusted for age, sex, current smoking and drinking status (yes/no), education (≥ 12 years or not), log-transformed physical activity, waist circumference, SBP, DBP, triglycerides, HDL-C, FPG, 2 h-PG, HbA1c, HOMA-IR and BMI. All covariates with the exception for sex and education were repeated measured both at baseline and follow-up and modelled as time-varying variables