Fig. 4

Lipid accumulation in the livers of PCSK9^−/− mice on control diet. Lipid composition of the liver was examined by HPLC–MS/MS. The concentration of TG, DG and CER subtypes (A, F, K), their total amount (B, G, L), the proportion of saturated and monounsaturated TGs, DGs and CERs to total amount (C, D, H, I, M, N) and the ratio of monounsaturated and saturated lipids were determined (E, J, O). Values are reported as mean ± SD; n = 5 in each group. The p value was determined by multiple T-test (A, F, K) or unpaired T-test (all others). *p < 0.05