Table 3 Supplementation trials with preparations high in 9CBC
Author | Description/dose | Isomer ratio and 9CBC amount | Purpose of study and beneficial activity outcome |
|---|---|---|---|
Stahl et al. [156] | 5.6 µmol BC/kg bw as a single dose of Betatene™; ~ 70 kg bw and ~ 5.6 µmol BC (~ 210 mg BC) | 54% ATBC: 37% 9CBC - > ~ 77.7 mg 9CBC/day | Absorption/accumulation study |
Johnson et al. [151] | Single treatment with dried algae powder | 64 mg ATBC (48%): 69 mg 9CBC (52%) - > ~ 69 mg 9CBC/day | Carotenoid nutri-kinetic study |
Shaish et al. [157] | Natural derived extract rich in BC with 60 mg/BC day for 6 weeks (42 days) | ~ 50% ATBC: 50% 9CBC - > ~ 30 mg 9CBC/day | Increase of HDL-cholesterol in fibrate treated patients |
Rotenstreich et al. [158] | Treatment for 90 days with capsules containing 300 mg 9CBC-rich dried algae containing ~ 20 mg BC | ~ 50% ATBC: 50% 9CBC - > ~ 10 mg 9CBC/day | Increased retinal functions in patients with Retinitis Pigmentosa |
Meshi et al. [159] | 1200 mg BC rich powder with ~ 20 mg BC content for 3 months (~ 90 days) | ~ 50% ATBC: 50% 9CBC - > ~ 10 mg 9CBC/day | Improvement and partly recovery of vision loss after ocular quintine toxicity |