Table 1 Detailed baseline characteristics of the study population for the HHPCP and CSPPT cohort
Variables | Controls (n = 1391) | Cases (n = 1391) | p value | Controls (n = 114) | Cases (n = 114) | p value |
|---|---|---|---|---|---|---|
Male, n (%) | 779 (56.0) | 776 (55.8) | 0.939 | 56 (49.1) | 56 (49.1) | 1.000 |
Age, y | 69.35 (7.78) | 69.35 (7.78) | 0.998 | 60.85 (7.14) | 60.86 (7.12) | 0.988 |
BMI, kg/m2 | 25.57 (23.19, 28.07) | 25.46 (23.12, 28.07) | 0.525 | 25.23 (23.31, 27.46) | 24.72 (22.76, 27.24) | 0.231 |
Family history of cancer | 47 (3.4) | 50 (3.6) | 0.836 | 0 (0.0) | 1 (0.9) | 1.000 |
Baseline SBP, mmHg | 147.33 (133.83, 160.33) | 146.00 (131.67, 161.00) | 0.314 | 162.33 (154.67, 180.00) | 162.00 (150.67, 172.50) | 0.205 |
Baseline DBP, mmHg | 83.00 (76.33, 90.33) | 82.67 (75.00, 91.00) | 0.249 | 96.67 (90.00, 101.83) | 94.00 (86.50, 100.67) | 0.281 |
History of diabetes, yes, no. (%) | 137 (9.8) | 191 (13.7) | 0.002 | 7 (6.1) | 3 (2.6) | 0.332 |
Smoking status (%) | 0.011 | 0.079 | ||||
Current | 334 (24.0) | 401 (28.8) | 33 (28.9) | 49 (43.0) | ||
Former | 160 (11.5) | 163 (11.7) | 8 (7.0) | 5 (4.4) | ||
Never | 897 (64.5) | 827 (59.5) | 73 (64.0) | 60 (52.6) | ||
Alcohol consumption status (%) | 0.359 | 0.735 | ||||
Current | 388 (27.9) | 370 (26.6) | 33 (28.9) | 30 (26.3) | ||
Former | 62 (4.5) | 77 (5.5) | 8 (7.0) | 11 (9.6) | ||
Never | 941 (67.6) | 944 (67.9) | 73 (64.0) | 73 (64.0) | ||
TC, mg/dL | 6.27 (5.38, 7.22) | 6.36 (5.53, 7.23) | 0.066 | 5.51 (4.81, 6.16) | 5.51 (4.72, 6.16) | 0.838 |
TG, mg/dL | 1.14 (0.80, 1.75) | 1.18 (0.81, 1.71) | 0.409 | 1.42 (1.19, 1.98) | 1.48 (1.17, 1.96) | 0.691 |
HDL-C, mg/dL | 1.16 (0.99, 1.36) | 1.19 (1.03, 1.36) | 0.033 | 1.19 (1.04, 1.47) | 1.25 (1.04, 1.43) | 0.785 |
Glucose, mmol/L | 5.80 (5.30, 6.50) | 5.80 (5.30, 6.50) | 0.826 | 5.72 (5.22, 6.41) | 5.46 (5.06, 6.12) | 0.120 |
Homocysteine, µg/mL | 12.01 (10.31, 14.66) | 12.25 (10.06, 15.02) | 0.904 | 13.00 (10.64, 17.00) | 12.77 (10.17, 16.36) | 0.389 |
Folate, ng/mL | 6.14 (4.00, 9.65) | 6.12 (4.23, 10.12) | 0.437 | 6.80 (5.25, 9.76) | 7.78 (4.98, 9.81) | 0.601 |
MTHFR C677T | 0.014 | 0.590 | ||||
CC | 339 (24.4) | 288 (20.7) | 26 (22.8) | 24 (21.1) | ||
CT | 832 (59.8) | 837 (60.2) | 59 (51.8) | 54 (47.4) | ||
TT | 220 (15.8) | 266 (19.1) | 29 (25.4) | 36 (31.6) | ||
Betaine, µg/mL | 5.73 (4.57, 7.11) | 5.80 (4.58, 7.26) | 0.401 | 9.38 (7.09, 11.83) | 10.15 (8.30, 13.66) | 0.036 |