The association of serum betaine concentrations with the risk of new-onset cancers: results from two independent nested case-control studies

Table 4 The relationship between the concentration of betaine and the risk of digestive cancer for the CSPPT cohort

Betaine, µg/ml	Cases/Controls	Crude Model	p value	Adjusted Model	p value
Betaine, µg/ml	Cases/Controls	OR (95%CI)	p value	OR (95%CI)	p value
Continuous	114/114	1.34(1.02,1.76)	0.038	1.48(1.06,2.05)	0.020
Quartiles
Quartile 1 (< 7.63)	22/35	Reference		Reference
Quartile 2 (7.63–9.66)	28/29	1.54 (0.73,3.23)	0.258	1.72 (0.75,3.94)	0.200
Quartile 3 (9.66–12.72)	30/27	1.77 (0.84,3.72)	0.134	1.58 (0.69,3.63)	0.281
Quartile 4 (≥ 12.72)	34/23	2.35 (1.11,4.98)	0.026	2.42 (1.06,5.53)	0.035
P for trend			0.025		0.042

Abbreviations: OR, odds ratios; CI, confidence intervals. Adjusted for age, BMI, sex, smoking, alcohol consumption, family history of cancer, diabetes, folate, homocysteine, systolic blood pressure, triglycerides, cholesterol, high-density lipoprotein cholesterol, glucose, and MTHFR C677T.

ISSN: 1743-7075