The effect of the modified fat-protein unit algorithm compared with that of carbohydrate counting on postprandial glucose in adults with type-1 diabetes when consuming meals with differing macronutrient compositions: a randomized crossover trial

Table 3 Indices of glycemic variability for test meals in 300 min (mean values and standard errors (SE), n = 30)

	NPM-a	NPM-b	HPFM-a	HPFM-b	p value NPM	p value HPFM
iAUC_0 − 30	173.93 ± 19.27	117.16 ± 33.57	79.80 ± 26.40	123.41 ± 25.77	0.076	0.136
iAUC_0 − 60	387.08 ± 48.34	222.81 ± 55.28	191.95 ± 53.17	281.73 ± 52.72	0.009	0.086
iAUC_0 − 90	673.00 ± 67.06	346.86 ± 73.22	358.00 ± 76.11	444.08 ± 76.56	0	0.239
iAUC_{0 − 120}	941.43 ± 97.38	463.95 ± 95.44	540.99 ± 94.32	605.08 ± 89.87	0	0.423
iAUC_{0 − 150}	1216.66 ± 132.71	584.33 ± 123.47	743.32 ± 111.99	786.78 ± 105.60	0.001	0.614
iAUC_{0 − 180}	1490.96 ± 168.40	700.71 ± 151.49	980.72 ± 118.91	993.13 ± 118.78	0.001	0.895
iAUC_{0 − 210}	1757.61 ± 201.06	825.33 ± 173.67	1234.49 ± 125.93	1193.68 ± 143.25	0.001	0.696
iAUC_{0 − 240}	2023.61 ± 226.07	971.93 ± 191.84	1485.59 ± 133.54	1404.08 ± 171.21	0.001	0.44
iAUC_{0 − 270}	2276.46 ± 248.54	1128.09 ± 210.08	1762.57 ± 148.23	1602.12 ± 200.92	0.001	0.249
iAUC_{0 − 300}	2521.63 ± 268.32	1275.13 ± 230.87	2031.22 ± 163.24	1788.71 ± 227.06	0.001	0.137
MAGE	5.07 ± 0.79	3.92 ± 0.61	3.23 ± 0.51	3.24 ± 0.59	0.259	0.989
∆Peak(mmol/L)	5.25 ± 0.74	2.62 ± 0.51	3.52 ± 0.45	3.22 ± 0.64	0.006	0.508
∆Low(mmol/L)	-0.65 ± 0.35	-2.21 ± 0.62	-0.62 ± 0.18	-0.75 ± 0.25	0.005	0.539

NPM-a, a normal protein meal based on CC; NPM-b, a normal protein meal based on the modified FPU method; HPFM-a, a high protein-fat meal based on CC; HPFM-b, a high protein-fat meal based on the modified FPU method. iAUC: incremental area under the glucose excursion curve; MAGE: mean amplitude of glycemic excursions

ISSN: 1743-7075