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Table 6 Multiple linear regression models between macrosomia and preteen cardiometabolic outcomes

From: The impact of macrosomia on cardiometabolic health in preteens: findings from the ROLO longitudinal birth cohort study

 

Model 1

Model 2

Model 3

B

95% CI

R2 adj

p

B

95% CI

R2 adj

p

B

95% CI

R2 adj

p

Models for birthweight ≥ 4 kg

SBP percentile

0.939

(− 4.336, 6.214)

− 0.003

0.726

0.746

(− 4.793, 6.284)

− 0.020

0.791

0.238

(− 5.303, 5.779)

− 0.007

0.933

DBP percentile

− 1.658

(− 7.059, 3.742)

− 0.002

0.546

− 0.834

(− 6.487, 4.819)

− 0.013

0.772

− 1.231

(− 6.929, 4.466)

− 0.015

0.671

Resting heart rate (bpm)

0.725

(− 2.184, 3.634)

− 0.003

0.624

1.520

(− 1.511, 4.550)

− 0.004

0.324

1.681

(− 1.363, 4.725)

0.001

0.278

20-M SRT score

0.171

(− 0.137, 0.478)

0.001

0.275

0.170

(− 0.136, 0.477)

0.085

0.274

0.203

(− 0.090, 0.497)

0.171

0.174

HOMA-IR

− 0.199

(− 0.984, 0.585)

− 0.004

0.617

− 0.313

(− 1.117, 0.491)

0.028

0.443

− 0.356

(− 1.150, 0.437)

0.067

0.376

TC (mmol/L)

− 0.131

(− 0.339, 0.077)

0.003

0.214

− 0.115

(− 0.333, 0.103)

− 0.010

0.297

− 0.128

(− 0.346, 0.091)

− 0.002

0.250

Triglycerides (mmol/L)

− 0.146

(− 0.332, 0.040)

0.008

0.123

− 0.145

(− 0.339, 0.050)

0.001

0.143

− 0.150

(− 0.343, 0.043)

0.031

0.126

LDL-C (mmol/L)

− 0.027

(− 0.195, 0.140)

− 0.005

0.748

− 0.024

(− 0.199, 0.152)

− 0.017

0.791

− 0.034

(− 0.210, 0.143)

− 0.011

0.705

HDL-C (mmol/L)

− 0.042

(− 0.155, 0.072)

− 0.003

0.470

− 0.029

(− 0.147, 0.089)

− 0.004

0.631

− 0.029

(− 0.147, 0.089)

0.007

0.630

C-reactive protein (mg/L)

− 0.097

(− 0.468, 0.274)

− 0.004

0.607

− 0.062

(− 0.455, 0.331)

− 0.037

0.757

− 0.071

(− 0.453, 0.312)

0.030

0.716

C3 complement (g/L)

− 0.070

(− 0.145, 0.005)

0.014

0.065

− 0.080

(− 0.156, − 0.005)

0.072

0.037

− 0.095

(− 0.162, − 0.029)

0.291

0.005

ICAM-1 (pg/mL)a

− 0.044

(− 0.091, 0.002)

0.019

0.062

− 0.042

(− 0.090, 0.007)

0.021

0.093

− 0.042

(− 0.091, 0.008)

0.008

0.097

TNF-α (pg/mL)

− 0.525

(− 1.453, 0.402)

0.002

0.265

− 0.624

(− 1.580, 0.333)

0.022

0.199

− 0.716

(− 1.670, 0.238)

0.041

0.140

GDF-15 (pg/mL)a

− 0.041

(− 0.091, 0.009)

0.012

0.105

− 0.032

(− 0.085, 0.021)

− 0.039

0.237

− 0.035

(− 0.089, 0.019)

− 0.054

0.196

sCD163 (pg/mL)a

− 0.037

(− 0.091, − 0.018)

0.006

0.183

− 0.041

(− 0.096, 0.013)

0.068

0.137

− 0.041

(− 0.096, 0.014)

0.080

0.143

Leptin (pg/mL)a

− 0.030

(− 0.186, 0.125)

− 0.006

0.701

0.005

(− 0.144, 0.155)

0.140

0.944

− 0.017

(− 0.123, 0.089)

0.573

0.751

IL-6 (pg/mL)

− 0.013

(− 0.309, 0.283)

− 0.008

0.931

0.058

(− 0.238, 0.354)

0.071

0.699

0.049

(− 0.247, 0.346)

0.079

0.743

IL-17A (pg/mL)

− 0.239

(− 0.609, 0.132)

0.005

0.205

− 0.293

(− 0.665, 0.079)

0.072

0.122

− 0.270

(− 0.648, 0.107)

0.061

0.158

Models for birthweight ≥ 4.5 kg

SBP percentile

2.585

(− 4.593, 9.763)

− 0.002

0.479

2.443

(− 5.177, 10.063)

− 0.019

0.529

1.678

(− 5.919, 9.274)

− 0.007

0.664

DBP percentile

− 6.124

(13.449, 1.200)

0.006

0.101

− 5.878

(13.631, 1.875)

− 0.006

0.137

− 6.463

(− 14.242, 1.315)

− 0.006

0.103

Resting heart rate (bpm)

− 0.731

(− 4.693, 3.231)

− 0.003

0.717

0.787

(− 3.391, 4.965)

− 0.007

0.711

0.578

(− 3.604, 4.761)

− 0.003

0.786

20-M SRT score

0.213

(− 0.206, 0.631)

0.000

0.318

0.326

(− 0.095, 0.747)

0.089

0.128

0.407

(0.006, 0.808)

0.177

0.047

HOMA-IR

0.560

(− 0.506, 1.626)

0.000

0.301

0.440

(− 0.667, 1.546)

0.028

0.434

0.338

(− 0.751, 1.428)

0.064

0.541

TC (mmol/L)

− 0.146

(− 0.430, 0.137)

0.000

0.311

− 0.058

(− 0.359, 0.243)

− 0.016

0.703

− 0.069

(− 0.369, 0.232)

− 0.009

0.652

Triglycerides (mmol/L)

0.123

(− 0.131, 0.377)

0.000

0.340

0.144

(− 0.124, 0.412)

− 0.005

0.290

0.125

(− 0.140, 0.390)

0.022

0.354

LDL-C (mmol/L)

− 0.183

(− 0.410, 0.044)

0.009

0.114

− 0.143

(− 0.384, 0.098)

− 0.009

0.244

− 0.149

(− 0.390, 0.092)

− 0.002

0.225

HDL-C (mmol/L)

− 0.035

(− 0.190, 0.120)

− 0.005

0.655

0.004

(− 0.59, 0.167)

− 0.006

0.964

0.008

(− 0.154, 0.170)

0.006

0.923

C-reactive protein (mg/L)

0.001

(− 0.505, 0.507)

− 0.006

0.996

− 0.005

(− 0.546, 0.536)

− 0.038

0.986

− 0.073

(− 0.598, 0.452)

0.029

0.785

C3 complement (g/L)

− 0.030

(− 0.133, 0.072)

− 0.004

0.560

− 0.051

(− 0.156, 0.054)

0.053

0.340

− 0.074

(− 0.166, 0.019)

0.266

0.118

ICAM-1 (pg/mL)a

− 0.038

(− 0.102, 0.026)

0.003

0.240

− 0.046

(− 0.114, 0.021)

0.013

0.174

− 0.049

(− 0.116, 0.019)

0.001

0.159

TNF-α (pg/mL)

− 0.116

(− 1.386, 1.153)

− 0.007

0.856

− 0.098

(− 1.424, 1.228)

0.009

0.884

− 0.207

(− 1.527, 1.113)

0.024

0.757

GDF-15 (pg/mL)a

− 0.020

(− 0.088, 0.048)

− 0.005

0.565

− 0.004

(− 0.077, 0.070)

− 0.051

0.918

− 0.005

(− 0.080, 0.069)

− 0.068

0.891

sCD163 (pg/mL)a

− 0.012

(− 0.087, 0.062)

− 0.007

0.744

− 0.033

(− 0.109, 0.043)

0.057

0.388

− 0.035

(− 0.111, 0.040)

0.070

0.358

Leptin (pg/mL)a

− 0.019

(− 0.230, 0.193)

− 0.007

0.862

− 0.036

(− 0.242, 0.170)

0.141

0.731

− 0.089

(− 0.234, 0.056)

0.578

0.226

IL-6 (pg/mL)

− 0.134

(− 0.536, 0.268)

− 0.004

0.510

− 0.105

(− 0.512, 0.302)

0.072

0.610

− 0.136

(− 0.542, 0.270)

0.082

0.508

IL-17A (pg/mL)

− 0.152

(− 0.658, 0.355)

− 0.005

0.555

− 0.191

(− 0.708, 0.325)

0.057

0.465

− 0.188

(− 0.709, 0.332)

0.049

0.475

  1. Models carried out as macrosomia and cardiometabolic outcomes at 9–11 years. alog10 transformed data was used. CI Confidence interval, SBP Systolic blood pressure, DBP Diastolic blood pressure, 20-M SRT 20-m shuttle run test, HOMA-IR Homeostatic Model Assessment for Insulin Resistance, TC Total cholesterol, LDL-C Low density lipoprotein cholesterol, HDL-C High density lipoprotein cholesterol, ICAM-1 Intracellular adhesion molecule 1, TNF-α Tumour necrosis factor alpha, GDF-15 Growth differentiation factor 15, sCD163 Soluble cluster of differentiation factor 163, IL Interleukin. Model 1: crude results; Model 2: adjusted for age at follow-up, study group allocation, sex, HP index, maternal age at delivery, maternal ethnicity, maternal early pregnancy BMI, gestational weight gain, maternal smoking in pregnancy; Model 3: adjusted for breastfeeding exposure, preteen BMI
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Nutrition & Metabolism

ISSN: 1743-7075

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