Fig. 5

Overexpression of CYP2B6 antagonize METTL3-mediated hepatic insulin resistance by regulating pIRS/IRS expression. Representative western blot analysis and quantification of IRS and pIRS expression in HepG2 from FFA group, METTL3^−/−group and FFA + METTL3^−/− group (A). Representative western blot analysis and quantification of IRS and pIRS expression in HepG2 from FFA group, CYP2B6^+/+group and FFA + CYP2B6^+/+ group (B). Representative western blot analysis and quantification of IRS and pIRS expression in mice liver from HFD + 0.9% NaCL group, HFD + DMSO group and HFD + STM2457 group (C). A schematic model related with the present study (D)