METTL3 exacerbates insulin resistance in hepatocytes by regulating m6A modification of cytochrome P450 2B6

Nutrition & Metabolism

Table 4 Top ten hypermethylation or hypomethylated CYP family mRNA information

Transcript_ID	Type	Regulation	Fold change	P value (unpaired t-test)	FDR	Gene Symbol
ENSMUST00000126645	Protein_coding	Hyper	1.3641138	0.0222037	0.4480289	Cyp4a31
ENSMUST00000005477	Protein_coding	Hyper	2.7213746	0.0112089	0.4199098	Cyp2b10
ENSMUST00000062474	Protein_coding	Hyper	1.2050972	0.0011335	0.3719519	Cyp8b1
ENSMUST00000084342	Protein_coding	Hyper	1.2079125	0.0020894	0.4127342	Cyp4a32
ENSMUST00000030299	Protein_coding	Hyper	1.330366	0.0135159	0.4224345	Cyp2j5
ENSMUST00000030303	Protein_coding	Hyper	1.3850063	0.0367759	0.4657982	Cyp2j6
NM_001357788	Protein_coding	Hypo	0.874955	0.0022313	0.4127342	Cyp4f14
ENSMUST00000055721	Protein_coding	Hypo	0.5825944	0.0085533	0.4199098	Cyp2d40
ENSMUST00000034865	Protein_coding	Hypo	0.8069894	0.0009762	0.3703641	Cyp1a1
ENSMUST00000211830	Protein_coding	Hypo	0.8845691	0.0217087	0.4456274	Cyp2c44
ENSMUST00000035571	Protein_coding	Hypo	0.879363	0.0464967	0.4750222	Cyp3a59
ENSMUST00000008801	Protein_coding	Hypo	0.878006	0.0273105	0.4551307	Cyp4f15
ENSMUST00000118278	Protein_coding	Hypo	0.8178247	0.0459065	0.47486	Cyp4a29
ENSMUST00000026211	Protein_coding	Hypo	0.8051967	0.0032982	0.4199098	Cyp2c44
ENSMUST00000023083	Protein_coding	Hypo	0.8450449	0.0232853	0.4498364	Cyp2d22
ENSMUST00000032908	Protein_coding	Hypo	0.7839067	0.0191123	0.4396346	Cyp2r1
ENSMUST00000228986	Protein_coding	Hypo	0.8361952	0.0241417	0.4500086	Cyp2d22
ENSMUST00000060608	Protein_coding	Hypo	0.7304229	0.0300979	0.4565687	Cyp20a1

ISSN: 1743-7075