Healthy lifestyle scores associate with incidence of type 2 diabetes mediated by uric acid

Nutrition & Metabolism

Table 3 Adjusted HR for association between baseline SUA and T2DM

Group^#	Number of T2DM	Person-year	Incidence per 1000 person-years	Model 1		Model 2
Group^#	Number of T2DM	Person-year	Incidence per 1000 person-years	HR (95% CI)	P	HR (95% CI)	P
Q1	117	31,373.42	3.73	1.00	–	1.00	–
Q2	126	31,590.78	3.99	0.97 (0.76, 1.25)	0.81	0.90 (0.70, 1.16)	0.40
Q3	146	31,395.91	4.65	1.05 (0.82, 1.34)	0.72	0.95 (0.75, 1.22)	0.66
Q4	229	29,984.09	7.64	1.56 (1.24, 1.96)	< 0.001	1.35 (1.07, 1.70)	0.011
P-trend	–	–	–	–	< 0.001	-	0.001
Per SD	–	–	–	1.26 (1.15,1.37)	< 0.001	1.18 (1.08, 1.29)	< 0.001
Hyperuricemia^*	164	21,109.42	7.77	1.61 (1.34,1.94)	< 0.001	1.43 (1.19, 1.72)	0.001

Model 1: adjusted for age, sex, healthy lifestyle scores (continuous), family history of diabetes, family history of hypertension, prevalence of hypertension, use of anti-hypertensive medication, and use of lipid-lowing medication
Model 2: Model1 + TG (mmol/L), HDL-C (mmol/L), and FPG (mmol/L)
^#sex-specific quartile of baseline SUA:74-, 312-, 363-, 423–768 µmol/L for male, 74-, 231-, 271-, 317–859 µmol/L for female
^*Hyperuricemia was defined as SUA ≥ 420 µmol/L for men and SUA ≥ 360 µmol/L for women
HR, hazard ratio; SUA, serum uric acid; T2DM, type 2 diabetes mellitus; CI, confidence interval; SD, standard deviation

ISSN: 1743-7075