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Table 5 Association of HLS with T2DM mediated by SUA

From: Healthy lifestyle scores associate with incidence of type 2 diabetes mediated by uric acid

Effects

SUA# (µmol/L)

Hyperuricemia†

Model 1

Model 2

Model 1

Model 2

β (95% CI)

P

β (95% CI)

P

β (95% CI)

P

β (95% CI)

P

Total effects

− 0.022

(− 0.033, − 0.013)

 < 0.001

− 0.016

(− 0.021, − 0.009)

 < 0.001

− 0.024

(− 0.034, − 0.014)

 < 0.001

− 0.017

(− 0.028, − 0.010)

 < 0.001

Direct effects

− 0.019

(− 0.028, − 0.010)

 < 0.001

− 0.014

(− 0.025, − 0.010)

 < 0.001

− 0.020

(− 0.029, − 0.011)

 < 0.001

− 0.014

(− 0.024, − 0.009)

 < 0.001

Indirect effects

− 0.003

(− 0.006, − 0.001)

 < 0.001

− 0.002

(− 0.004, − 0.002)

 < 0.001

− 0.004

(− 0.005, − 0.002)

 < 0.001

− 0.003

(− 0.004, − 0.001)

 < 0.001

Proportion of

mediation (%) *

14.38

(5.28, 26.01)

 < 0.001

13.06

(6.29, 30.22)

 < 0.001

16.07

(9.87, 27.18)

 < 0.001

15.71

(6.69, 33.12)

 < 0.001

  1. Model 1: unadjusted model
  2. Model 2: age, sex, family history of hypertension, use of anti-hypertensive medication, and use of lipid-lowing medication
  3. #The levels of SUA were nature log-transformed
  4. †Hyperuricemia was defined as SUA ≥ 420 µmol/L for men and SUA ≥ 360 µmol/L for women
  5. *1000 bootstrap resampling
  6. HLS, healthy lifestyle scores; T2DM, type 2 diabetes mellitus; SUA, serum uric acid; CI, confidence interval
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Nutrition & Metabolism

ISSN: 1743-7075

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