Fig. 1

Network analysis of the human flavoproteome. Human flavoproteome genes (Additional file 1: Table S1) were subjected to network analysis using STRING (v11.5, 17/3/2023) using a high confidence interaction score of 0.7. Gene clusters were identified in which the colour nodes represent functional groups in which the thickness of the edges corresponds to confidence of association between genes. The major functional groups identified in the human flavoproteome are (i) mitochondrial metabolism (red), (ii) riboflavin transport (purple), (iii) ubiquinone and FAD synthesis (orange), (iv) antioxidant signalling (yellow), (v) one-carbon metabolism (green), (vi) nitric oxide signalling (pink) and (vii) peroxisome oxidative metabolism (blue)