Fig. 4
From: New insights into the nutritional genomics of adult-onset riboflavin-responsive diseases
Riboflavin-responsive mutants of ACAD9. The alignment was generated for known (or predicted) ACAD9 sequences from human (Homo sapiens NP_054768.2), pig (Sus scrofa, XP_020925064.1), mouse (Mus musculus, NP_766266.3), frog (Xenopus laevis, NP_001086893.1), zebra fish (Danio rerio, NP_001038772.1), worm (Caenorhabditis elegans, NP_501452.1), nematode (Trichinella pseudospiralis KRX97230.1), fruit fly (Drosophila melanogaster, NP_001286611.1), fungus (Absidia glauca, ABSGL08664) and bacteria (Proteobacteria, MCE3013325.1) using ClustalX 2.1 [113]. Amino acid numbers for the human sequence are indicated. Red boxes indicate the locations of the human variant amino acids Glu413, Arg414, Asp418, Arg518, Lys521, Arg532, Val546 and His563 that are associated with adult-onset riboflavin-responsive disease. The red arrow indicates the location of Arg417 for which mutants would be predicted to be associated with riboflavin-responsive diseases