Table 2 Risk for CVD events and diabetes related to weight change patterns
Outcomes | Model | Weight change between age 20 years and 40 years | ||||
|---|---|---|---|---|---|---|
Weight loss > 2.5 kg | Weight loss ≤ 2.5 kg or gain < 2.5 kg | Weight gain between ≥ 2.5 kg and < 5.0 kg | Weight gain between ≥ 5.0 kg and < 10.0 kg | Weight gain ≥ 10.0 kg | ||
CVD events | Cases/ Total number | 86 / 3,977 | 290 / 13,618 | 104 / 6,200 | 370 / 16,544 | 415 / 19,209 |
CVD incidence | 2.16% | 2.13% | 1.68% | 2.24% | 2.16% | |
Hazard ratios (95%CI) | ||||||
Model 1 | 1.13 (0.89–1.44) | 1 [Reference] | 0.92 (0.73–1.15) | 1.28 (1.10–1.49) | 1.52 (1.30–1.77) | |
Model 2 | 1.14 (0.89–1.46) | 1 [Reference] | 0.92 (0.73–1.15) | 1.27 (1.09–1.48) | 1.49 (1.28–1.74) | |
Model 3 | 1.26 (0.99–1.61) | 1 [Reference] | 0.86 (0.69–1.08) | 1.14 (0.98–1.34) | 1.22 (1.04–1.43) | |
Diabetes | Cases/ Total number | 155 / 3,443 | 632 / 11,176 | 312 / 5,090 | 858 / 13,075 | 1179 / 14,024 |
Diabetes incidence | 4.50% | 5.65% | 6.13% | 6.56% | 8.41% | |
Hazard ratios (95%CI) | ||||||
Model 1 | 0.79 (0.66–0.95) | 1 [Reference] | 1.18 (1.03–1.35) | 1.25 (1.13–1.39) | 1.69 (1.53–1.86) | |
Model 2 | 0.80 (0.67–0.95) | 1 [Reference] | 1.17 (1.02–1.34) | 1.24 (1.12–1.38) | 1.67 (1.51–1.84) | |
Model 3 | 0.88 (0.74–1.05) | 1 [Reference] | 1.09 (0.95–1.25) | 1.12 (1.01–1.24) | 1.38 (1.25–1.53) | |