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Fig. 6 | Nutrition & Metabolism

Fig. 6

From: D-mannose promotes the degradation of IDH2 through upregulation of RNF185 and suppresses breast cancer

Fig. 6

Knockdown of RNF185 abrogates the effect of D-mannose on tumor cells. (A) Relative levels of NADPH in MDA-MB-231 cells with indicated treatment. Values are means ± SD from n = 3 independent experiments. Statistical differences were determined by t-test. ****p < 0.0001. (B) Cell proliferation analysis of MDA-MB-231 cells with indicated treatment. Values are means ± SD from n = 3 independent experiments. Statistical differences were determined by t-test. ****p < 0.0001. (C) Relative survival analysis of MDA-MB-231 cells under the indicated treatments for 48 h. Values are means ± SD from n = 3 independent experiments. Statistical differences were determined by t-test. ****p < 0.0001. (D) Schematic representation of the mechanism under D-mannose mediated IDH2 degradation

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Nutrition & Metabolism

ISSN: 1743-7075

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