Fig. 2

Activation of SIRT1 through RV has exhibited a range of potential benefits in brain cells. These benefits encompass neuroprotection against degeneration, increased neuronal survival, improved synaptic plasticity, anti-inflammatory properties, and enhanced blood flow and neurovascular health. RV-induced SIRT1 activation aids in reducing oxidative stress, enhancing mitochondrial function, and facilitating the clearance of toxic protein aggregates like Aβ plaques and tau tangles. Furthermore, SIRT1 plays a critical role in regulating synaptic plasticity and neurogenesis for optimal learning and memory, in particular among those who suffering from AD