Consumption of dietary fiber and APOA5 genetic variants in metabolic syndrome: baseline data from the Korean Medicine Daejeon Citizen Cohort Study

Table 4 Interaction between dietary fiber intake and APOA5 genetic variants regarding metabolic syndrome risk

APOA5	Non-MetS/MetS		Crude OR (95% CI)		P for interaction	Multivariable OR (95% CI)		P for interaction
SNPs	Low	High	Low	High	P for interaction	Low	High	P for interaction
rs2266788
Dominant
A/A	527/96	524/75	1.0 (ref)	0.79 (0.57–1.09)	0.63	1.0 (ref)	0.78 (0.54–1.13)	0.69
A/G + G/G	312/77	315/54	1.36 (0.97–1.89)	0.94 (0.66–1.35)		1.43 (0.98–2.09)	1.00 (0.66–1.51)
Recessive
A/A + A/G	792/163	805/122	1.0 (ref)	0.74 (0.57–0.95)	0.62	1.0 (ref)	0.74 (0.55–0.99)	0.78
G/G	47/10	34/7	1.03 (0.51–2.09)	1.00 (0.44–2.30)		1.13 (0.52–2.46)	0.98 (0.40–2.42)
rs662799
Dominant
A/A	447/63	430/60	1.0 (ref)	0.99 (0.68–1.44)	0.05	1.0 (ref)	1.07 (0.70–1.63)	0.024
A/G + G/G	393/109	410/69	1.97 (1.40–2.76)	1.19 (0.83–1.72)		2.34 (1.59–3.44)	1.30 (0.86–1.98)
Recessive
A/A + A/G	770/149	770/110	1.0 (ref)	0.74 (0.57–0.96)	0.77	1.0 (ref)	0.73 (0.54–0.99)	0.79
G/G	70/23	70/19	1.70 (1.03–2.81)	1.40 (0.82–2.40)		1.99 (1.12–3.53)	1.62 (0.89–2.96)
rs651821
Dominant
T/T	441/62	422/59	1.0 (ref)	0.99 (0.68–1.46)	0.06	1.0 (ref)	1.07 (0.70–1.63)	0.027
T/C + C/C	392/109	412/70	1.98 (1.41–2.78)	1.21 (0.84–1.75)		2.35 (1.59–3.46)	1.32 (0.87–2.01)
Recessive
T/T + T/C	764/148	764/110	1.0 (ref)	0.74 (0.57–0.97)	0.81	1.0 (ref)	0.73 (0.54-1.00)	0.85
C/C	69/23	70/19	1.72 (1.04–2.85)	1.40 (0.82–2.40)		2.05 (1.15–3.66)	1.63 (0.89–2.98)

MetS, metabolic syndrome; CI, 95% confidence intervals; OR, odds ratios. Dietary fiber intake was categorized into low and high groups based on the median level. P-values were calculated using the chi-square test. Multivariable model was adjusted for age, sex, BMI, education level, occupation, income, alcohol consumption, smoking status, and physical activity

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