|
• Counteracts smooth muscle cell proliferation.
|
|
• Decreases platelet adhesiveness.
|
|
• Decreases adhesiveness of the endothelial layer to monocytic WBCs (the "teflon effect").
|
|
• Anti-inflammatory effect.
|
|
• Anti-oxidant effect. It scavenges reactive oxygen species locally, and acts as a chain-breaking antioxidant to scavenge ROS.
|
|
• Anti-fibrotic effect. When NO is normal or elevated, MMPs are quiescent; conversely if NO is low, MMPs are elevated and active.
|
|
MMPs are redox sensitive.
|
|
• No inhibits prooxidant actions of uric acid during copper-mediated LDL oxidation.
|
|
• NO has diverse anti-atherosclerotic actions on the arterial vessel wall including antioxidant effects by direct scavenging of ROS – RNS acting as chain-breaking antioxidants and it also has anti-inflammatory effects.
|
