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Table 6 The positive effects of eNOS and eNO

From: Uric acid: A new look at an old risk marker for cardiovascular disease, metabolic syndrome, and type 2 diabetes mellitus: The urate redox shuttle

• Promotes vasodilatation of vascular smooth muscle.
• Counteracts smooth muscle cell proliferation.
• Decreases platelet adhesiveness.
• Decreases adhesiveness of the endothelial layer to monocytic WBCs (the "teflon effect").
• Anti-inflammatory effect.
• Anti-oxidant effect. It scavenges reactive oxygen species locally, and acts as a chain-breaking antioxidant to scavenge ROS.
• Anti-fibrotic effect. When NO is normal or elevated, MMPs are quiescent; conversely if NO is low, MMPs are elevated and active.
   MMPs are redox sensitive.
• No inhibits prooxidant actions of uric acid during copper-mediated LDL oxidation.
• NO has diverse anti-atherosclerotic actions on the arterial vessel wall including antioxidant effects by direct scavenging of ROS – RNS acting as chain-breaking antioxidants and it also has anti-inflammatory effects.