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  1. Content type: Research

    Small dense LDL cholesterol (sdLDL-c) has been established to be highly associated with metabolic disorder. However, the relationship between circulating sdLDL-c and the presence of metabolic syndrome (MetS) h...

    Authors: Jiahua Fan, Yangqing Liu, Songping Yin, Nixuan Chen, Xinxiu Bai, Qiuyi Ke, Jia Shen and Min Xia

    Citation: Nutrition & Metabolism 2019 16:7

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  2. Content type: Research

    Obesity has become a public health concern worldwide because it is linked to numerous metabolic disorders, such as hyperlipidemia, hypertension and cardiovascular disease. Therefore, there is an urgent need to...

    Authors: Licong Yang, Yan Zhao, Yongfang Pan, Dongming Li and Guodong Zheng

    Citation: Nutrition & Metabolism 2019 16:6

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  3. Content type: Research

    The GC haplotype of the vitamin D binding protein (encoded by the GC gene) might be a risk factor to the vitamin D (VD) nutritional status for many populations, while evidences from the Chinese Han population are...

    Authors: Ji-Chang Zhou, Yumei Zhu, Chunmei Gong, Xiongshun Liang, Xiaoying Zhou, Yuanfei Xu, Deliang Lyu, Junluan Mo, Jian Xu, Jinping Song, Xiaoling Che, Shiqiang Sun, Changhua Huang and Xiao-Li Liu

    Citation: Nutrition & Metabolism 2019 16:5

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  4. Content type: Research

    Osteoporosis is one of the world’s major medical burdens in the twenty-first century. Pharmaceutical intervention currently focusses on decelerating bone loss, but phytochemicals such as baicalein, which is a ...

    Authors: Dominik Saul, Marie Weber, Marc Hendrik Zimmermann, Robyn Laura Kosinsky, Daniel Bernd Hoffmann, Björn Menger, Stefan Taudien, Wolfgang Lehmann, Marina Komrakova and Stephan Sehmisch

    Citation: Nutrition & Metabolism 2019 16:4

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  5. Content type: Research

    Although retinol binding protein 4 (RBP4) has been implicated in insulin resistance in experimental studies, the association between RBP4 and risk of type 2 diabetes remains unclear. We assessed this associati...

    Authors: Yeli Wang, Liang Sun, Xu Lin, Jian-Min Yuan, Woon-Puay Koh and An Pan

    Citation: Nutrition & Metabolism 2019 16:3

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  6. Content type: Research

    Effective evaluation or prediction of therapy response could be helpful for treatment of chronic kidney disease (CKD), which may rely on accurate biomarkers. Acylcarnitines are involved with lipid metabolism a...

    Authors: Fang-Ying Xia, Li Zhu, Chao Xu, Qing-Qing Wu, Wan-Jia Chen, Rong Zeng and Yue-Yi Deng

    Citation: Nutrition & Metabolism 2019 16:2

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  7. Content type: Research

    Increased consumption of linoleic acid (LA, omega-6) in Western diets coupled with the pro-inflammatory and adipogenic properties of its derivatives has led to suggestions that fetal exposure to this dietary p...

    Authors: Sally A. V. Draycott, Ge Liu, Zoe C. Daniel, Matthew J. Elmes, Beverly S. Muhlhausler and Simon C. Langley-Evans

    Citation: Nutrition & Metabolism 2019 16:1

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  8. Content type: Research

    Higher dietary intake of fibers and coffee, but lower red meat intake is associated with reduced risk for type 2 diabetes in epidemiological studies. We hypothesized that a calorie-restricted diet, which is hi...

    Authors: Yanislava Karusheva, Lejla Kunstein, Alessandra Bierwagen, Bettina Nowotny, Stefan Kabisch, Jan B. Groener, Ann Kristin Fleitmann, Christian Herder, Giovanni Pacini, Klaus Strassburger, Hans-Ulrich Häring, Peter P. Nawroth, Andreas F. H. Pfeiffer, Volker Burkart, Karsten Müssig, Michael Roden…

    Citation: Nutrition & Metabolism 2018 15:90

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  9. Content type: Research

    Several studies have identified a negative association between serum glycine (Gly) levels and metabolic syndrome (MetS). However, this association has not been fully established in the elderly.

    Authors: Xianghui Li, Liang Sun, Wenduo Zhang, Hongxia Li, Siming Wang, Hongna Mu, Qi Zhou, Ying Zhang, Yueming Tang, Yu Wang, Wenxiang Chen, Ruiyue Yang and Jun Dong

    Citation: Nutrition & Metabolism 2018 15:89

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  10. Content type: Research

    Although dietary patterns have been linked to chronic diseases such as cardiovascular disease, sparse data are available for a relationship between dietary patterns and incident chronic kidney disease (CKD) in...

    Authors: Golaleh Asghari, Mehrnaz Momenan, Emad Yuzbashian, Parvin Mirmiran and Fereidoun Azizi

    Citation: Nutrition & Metabolism 2018 15:88

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  11. Content type: Research

    In a previous study, we showed that consumption of diets enriched in saturated fatty acids causes changes in alternative splicing of pre-mRNAs encoding a number of proteins in rat skeletal muscle, including th...

    Authors: Adam J. Black, Rudolf J. Schilder and Scot R. Kimball

    Citation: Nutrition & Metabolism 2018 15:87

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  12. Content type: Research

    Non-alcoholic fatty liver disease (NAFLD) is a chronic and progressive liver disease with an increased risk of morbidity and mortality. However, so far no specific pharmacotherapy has been approved. Gynostemma pe...

    Authors: Ning Jia, Xiaoyan Lin, Shizhan Ma, Shujian Ge, Shumin Mu, Chongbo Yang, Shulong Shi, Ling Gao, Jin Xu, Tao Bo and Jiajun Zhao

    Citation: Nutrition & Metabolism 2018 15:86

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  13. Content type: Review

    The current systematic review and meta-analysis of randomized controlled trials (RCTs) was conducted to summarize the effect of vitamin D supplementation on endothelial activation among patients with metabolic...

    Authors: Reza Tabrizi, Maryam Akbari, Kamran B. Lankarani, Seyed Taghi Heydari, Fariba Kolahdooz and Zatollah Asemi

    Citation: Nutrition & Metabolism 2018 15:85

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  14. Content type: Research

    It has been proved that coffee consumption was associated with a lower risk of type 2 diabetes mellitus. But the benefit effect of coffee on hyperglycemia in Chinese population was largely unknown. Besides, th...

    Authors: Fei Gao, Yinan Zhang, Sheng Ge, Huijuan Lu, Ruihua Chen, Pingyan Fang, Yixie Shen, Congrong Wang and Weiping Jia

    Citation: Nutrition & Metabolism 2018 15:84

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  15. Content type: Research

    Salvia hispanica seeds have been commonly used by people that seek healthy habits through natural foods to reduce cholesterol and triacylglycerides levels, however, the evidences that support this assumption are ...

    Authors: Cristiane Freitas Rodrigues, Willian Salgueiro, Matheus Bianchini, Juliana Cristina Veit, Robson Luiz Puntel, Tatiana Emanuelli, Cristiane Casagrande Dernadin and Daiana Silva Ávila

    Citation: Nutrition & Metabolism 2018 15:83

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  16. Content type: Research

    Fasting and especially intermittent fasting have been shown to be an effective intervention in many diseases, such as obesity and diabetes. The fasting-mimicking diet (FMD) has recently been found to ameliorat...

    Authors: Siying Wei, Ruomei Han, Jingyu Zhao, Shuo Wang, Meiqin Huang, Yining Wang and Yan Chen

    Citation: Nutrition & Metabolism 2018 15:80

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  17. Content type: Research

    Consumption of fructose-rich diets has been implicated in the increasing global prevalence of metabolic syndrome (MetS). Interventions during periods of early ontogenic developmental plasticity can cause epige...

    Authors: Trevor T. Nyakudya, Emmanuel Mukwevho and Kennedy H. Erlwanger

    Citation: Nutrition & Metabolism 2018 15:82

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  18. Content type: Research

    Evidence has suggested a potential link exists between trimethylamine-N-oxide (TMAO), a choline-derived metabolite produced by gut microbiota, and some cancers, but little is known for primary liver cancer (PLC).

    Authors: Zhao-Yan Liu, Xu-Ying Tan, Qi-Jiong Li, Gong-Cheng Liao, Ai-Ping Fang, Dao-Ming Zhang, Pei-Yan Chen, Xiao-Yan Wang, Yun Luo, Jing-An Long, Rong-Huan Zhong and Hui-Lian Zhu

    Citation: Nutrition & Metabolism 2018 15:81

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  19. Content type: Research

    Sex hormone-binding globulin (SHBG), a glycoprotein synthesized by hepatocytes, has been linked to insulin resistance and hepatic lipid metabolism and is suggested to be associated with nonalcoholic fatty live...

    Authors: Jing Luo, Qian Chen, Tianran Shen, Xu Wang, Wanjun Fang, Xiaocai Wu, Zenan Yuan, Gengdong Chen, Wenhua Ling and Yuming Chen

    Citation: Nutrition & Metabolism 2018 15:79

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  20. Content type: Brief communication

    Visceral adipose tissue (VAT) area is a strong predictor of obesity-related cardiometabolic alterations, but its measurement is costly, time consuming and, in some cases, involves radiation exposure. Glutamate...

    Authors: Ina Maltais-Payette, Marie-Michèle Boulet, Cornelia Prehn, Jerzy Adamski and André Tchernof

    Citation: Nutrition & Metabolism 2018 15:78

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  21. Content type: Research

    Previous studies in teleost have demonstrated the adaptive strategy to maintain hepatic lipid homeostasis within certain limit. The excess of fat-intake could induce abnormal lipid deposition in liver but not ...

    Authors: Jie Wang, Xu-Fang Liang, Shan He, Jiao Li, Kang Huang, Yan-Peng Zhang and Dong Huang

    Citation: Nutrition & Metabolism 2018 15:77

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  22. Content type: Research

    Bariatric surgery is a widely adopted treatment for obesity and its secondary complications. In the past decade, microvesicles (MVs) and CD36 have increasingly been considered as possible biomarkers for obesit...

    Authors: Jaco Botha, Morten Hjuler Nielsen, Maja Høegh Christensen, Henrik Vestergaard and Aase Handberg

    Citation: Nutrition & Metabolism 2018 15:76

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  23. Content type: Research

    An ability to switch between primarily oxidizing fat in the fasted state to carbohydrate in the fed state, termed metabolic flexibility, is associated with insulin sensitivity. Metabolic flexibility has been e...

    Authors: Nicholas T. Broskey, Charmaine S. Tam, Elizabeth F. Sutton, Abby D. Altazan, Jeffrey H. Burton, Eric Ravussin and Leanne M Redman

    Citation: Nutrition & Metabolism 2018 15:75

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  24. Content type: Review

    Advanced glycation end products (AGEs), a group of compounds that are formed by non-enzymatic reactions between carbonyl groups of reducing sugars and free amino groups of proteins, lipids or nucleic acids, ca...

    Authors: Jie-Hua Chen, Xu Lin, Cuihong Bu and Xuguang Zhang

    Citation: Nutrition & Metabolism 2018 15:72

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  25. Content type: Research

    Diabetes mellitus is one of the most common chronic diseases that accompanied by severe complications. Gynura divaricata (GD), a medicinal and edible plant that is usually used for the treatment of diabetes. Ther...

    Authors: Xiao-Lu Yin, Bing-Qing Xu and Yu-Qing Zhang

    Citation: Nutrition & Metabolism 2018 15:73

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  26. Content type: Research

    This study aimed to assess the association between the angiopoietin-like protein 4 gene (ANGPTL4) single nucleotide polymorphisms (SNPs) and serum lipid levels, the risk of coronary artery disease (CAD) and ische...

    Authors: Qian Yang, Rui-Xing Yin, Xiao-Li Cao, Feng Huang, Yi-Jiang Zhou and Wu-Xian Chen

    Citation: Nutrition & Metabolism 2018 15:70

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  27. Content type: Research

    Non-alcoholic fatty liver disease (NAFLD) covers a spectrum of lesions ranging from steatosis to a complex pattern, nonalcoholic steatohepatitis (NASH). Ultrasonography provides important information on hepati...

    Authors: Guozhen Cui, Robert C Martin, Xingkai Liu, Qianqian Zheng, Harshul Pandit, Ping Zhang, Wei Li and Yan Li

    Citation: Nutrition & Metabolism 2018 15:71

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  28. Content type: Research

    Metabolic Syndrom has become a public health problem. It mainly results from the increased consumption of fat and sugar. In this context, the benefits of personalized moderate exercise training were investigat...

    Authors: Julie Dupas, Annie Feray, Anthony Guernec, Morgane Pengam, Manon Inizan, François Guerrero, Jacques Mansourati and Christelle Goanvec

    Citation: Nutrition & Metabolism 2018 15:69

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  29. Content type: Research

    Weight loss, especially fat mass reduction, helps to improve blood glucose control, insulin sensitivity, and β-cell function. This study aimed to compare the effect of exenatide and glargine on body compositio...

    Authors: Ting-Ting Yin, Yan Bi, Ping Li, Shan-Mei Shen, Wei-Min Wang, Can Jiang, Cai-Xia Gao, Yan Wang, Li-Jun Gao, Da-Long Zhu and Wen-Huan Feng

    Citation: Nutrition & Metabolism 2018 15:67

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  30. Content type: Review

    MicroRNAs (miRNAs), a class of single-stranded non-coding RNA of about 22 nucleotides, are potent regulators of gene expression existing in both plants and animals. Recent studies showed that plant miRNAs coul...

    Authors: Zhiqing Li, Ruodan Xu and Ning Li

    Citation: Nutrition & Metabolism 2018 15:68

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    The Correction to this article has been published in Nutrition & Metabolism 2018 15:74

  31. Content type: Research

    Increased oxidative stress and impaired antioxidant defense are important mechanisms in the pathogenesis of diabetic myopathy. Alpha-lipoic acid (ALA) has been indicated as a weight-loss treatment in rodents a...

    Authors: Oak-Kee Hong, Jang-Won Son, Hyuk-Sang Kwon, Seong-Su Lee, Sung-Rae Kim and Soon Jib Yoo

    Citation: Nutrition & Metabolism 2018 15:66

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  32. Content type: Research

    We previously reported on the anti-obesogenic and anti-inflammatory effects associated with n-3 long-chain polyunsaturated fatty acids (LCPUFA) in our diet-induced obesity (DIO) mouse model. Two isocaloric hig...

    Authors: Stefanie Worsch, Mathias Heikenwalder, Hans Hauner and Bernhard L. Bader

    Citation: Nutrition & Metabolism 2018 15:65

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  33. Content type: Research

    Non-alcoholic fatty liver disease (NAFLD) is the hepatic component of metabolic syndrome. Despite the beneficial health effects of cardamom on dyslipidemia, hepatomegaly, and fasting hyperglycemia, no previous...

    Authors: Milad Daneshi-Maskooni, Seyed Ali Keshavarz, Mostafa Qorbani, Siavash Mansouri, Seyed Moayed Alavian, Mahtab Badri-Fariman, Seyed Ali Jazayeri-Tehrani and Gity Sotoudeh

    Citation: Nutrition & Metabolism 2018 15:63

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  34. Content type: Research

    Dietary interventions have been shown to attenuate some of the myocardial pathological alterations associated with obesity. This study evaluated the effect of dietary normalization from a fat/fructose/choleste...

    Authors: Laura Jul Andreasen, Simone Krog, Trine Pagh Ludvigsen, Ole Lerberg Nielsen, Jacob Eifer Møller, Berit Østergaard Christoffersen, Henrik Duelund Pedersen and Lisbeth Høier Olsen

    Citation: Nutrition & Metabolism 2018 15:64

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  35. Content type: Research

    Muscle protein synthesis and muscle net balance plateau after moderate protein ingestion in adults. However, it has been suggested that there is no practical limit to the anabolic response of whole-body net ba...

    Authors: Michael Mazzulla, Kimberly A. Volterman, Jeff E. Packer, Denise J. Wooding, Jahmal C. Brooks, Hiroyuki Kato and Daniel R. Moore

    Citation: Nutrition & Metabolism 2018 15:62

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  36. Content type: Research

    Regular-fat cheese does not seem to increase low density lipoprotein cholesterol (LDL-C) concentrations compared to reduced-fat cheese. However, plasma LDL-C concentrations do not reflect levels and size of LD...

    Authors: Farinaz Raziani, Parvaneh Ebrahimi, Søren Balling Engelsen, Arne Astrup, Anne Raben and Tine Tholstrup

    Citation: Nutrition & Metabolism 2018 15:61

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  37. Content type: Research

    γ-Aminobutyric acid (GABA) is a major inhibitory neurotransmitter in the central nervous system and reported to maintain the redox homeostasis and insulin secretion function of pancreatic β cells. This study t...

    Authors: Xue Tang, Renqiang Yu, Qin Zhou, Shanyu Jiang and Guowei Le

    Citation: Nutrition & Metabolism 2018 15:60

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  38. Content type: Research

    Previous studies have revealed the inductive effect of branched-chain amino acids (BCAAs) catabolism on fatty acid oxidation and metabolism, especially in muscle cells. In the present investigation, we have at...

    Authors: Navid Abedpoor, Farzaneh Taghian, Kamran Ghaedi, Iman Niktab, Zahra Safaeinejad, Farzaneh Rabiee, Sommayeh Tanhaei and Mohammad Hossein Nasr-Esfahani

    Citation: Nutrition & Metabolism 2018 15:59

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  39. Content type: Research

    Individuals’ peak bone mineral density (BMD) achieved and maintained at ages 20–40 years is the most powerful predictor of low bone mass and osteoporotic fractures later in life. The aim of this study was to i...

    Authors: Qi Zhao, Hui Shen, Kuan-Jui Su, Ji-Gang Zhang, Qing Tian, Lan-Juan Zhao, Chuan Qiu, Qiang Zhang, Timothy J. Garrett, Jiawang Liu and Hong-Wen Deng

    Citation: Nutrition & Metabolism 2018 15:57

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  40. Content type: Research

    The effects of vitamin D on the immune function of laying hens are not well understood. This study investigated the effects of vitamin D3 (VD3) on laying performance and immunological functions in laying hens und...

    Authors: Yanqiang Geng, Qiugang Ma, Zhong Wang and Yuming Guo

    Citation: Nutrition & Metabolism 2018 15:58

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  41. Content type: Research

    The aim in this study was to investigate the effect of vitamin D (25(OH)D3) supplementation on heat shock protein 60 (HSP 60) and other inflammatory markers (IL-17, TNF-α, PAB) in patients with coronary heart dis...

    Authors: Leila Sadat Bahrami, Seyed Hashem Sezavar Seyedi Jandaghi, Leila Janani, Mina Pahlavan, Seyed Mostafa Arabi, Homa Sadeghi and Mohammadreza Vafa

    Citation: Nutrition & Metabolism 2018 15:56

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  42. Content type: Research

    Reducing caloric intake is a proven intervention for mitigating and modulating morbidities associated with overnutrition. Caloric restriction is difficult to affect clinically, therefore, dietary interventions...

    Authors: Julie K. Bray, Gabriel S. Chiu, Leslie K. McNeil, Morgan L. Moon, Robyn Wall, Albert E. Towers and Gregory G. Freund

    Citation: Nutrition & Metabolism 2018 15:55

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  43. Content type: Research

    Very low carbohydrate (VLC) diets are used to promote weight loss and improve insulin resistance (IR) in obesity. Since the high fat content of VLC diets may predispose to hepatic steatosis and hepatic insulin...

    Authors: Kathleen V. Axen, Marianna A. Harper, Yu Fu Kuo and Kenneth Axen

    Citation: Nutrition & Metabolism 2018 15:54

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  44. Content type: Research

    Consumption of added sugars has been considered a worldwide public health concern by its association with metabolic syndrome and its comorbidities. Meanwhile, current studies have suggested high-protein diets ...

    Authors: Rosângela Maria Lopes Sousa, Nathalee Liberal Xavier Ribeiro, Bruno Araújo Serra Pinto, Jonas Rodrigues Sanches, Mariana Uchôa da Silva, Caio Fernando Ferreira Coêlho, Lucas Martins França, José Albuquerque de Figueiredo Neto and Antonio Marcus de Andrade Paes

    Citation: Nutrition & Metabolism 2018 15:53

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  45. Content type: Research

    Previous intervention studies have reported the association of the PPARG2 Pro12Ala (rs1801282) and IL6 -174G > C (rs1800795) polymorphisms with weight loss; however, their results are inconsistent. We aimed to in...

    Authors: Ana Paula Santos Rodrigues, Lorena Pereira Souza Rosa and Erika Aparecida Silveira

    Citation: Nutrition & Metabolism 2018 15:52

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  46. Content type: Research

    Obesity and comorbidities such as non-alcoholic fatty liver disease (NAFLD) are major public health burdens. Alterations in lipid metabolism are involved in hepatic diseases. The objective of this study was to...

    Authors: Irene Cantero, Itziar Abete, Josep Maria del Bas, Antoni Caimari, Lluís Arola, M. Angeles Zulet and J. Alfredo Martinez

    Citation: Nutrition & Metabolism 2018 15:51

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  47. Content type: Research

    Excess weight is a strong risk factor for the development of dysglycaemia. It has been suggested that changes in the metabolism microRNAs, small non-coding RNAs that regulate gene expression, could precede lat...

    Authors: Rafaella Cristhine Pordeus Luna, Mayara Karla dos Santos Nunes, Mussara Gomes Cavalcante Alves Monteiro, Cássia Surama Oliveira da Silva, Rayner Anderson Ferreira do Nascimento, Raquel Patrícia Ataíde Lima, Flávia Cristina Fernandes Pimenta, Naila Francis Paulo de Oliveira, Darlene Camati Persuhn, Aléssio Tony Cavalcanti de Almeida, Alcides da Silva Diniz, Cristina Wide Pissetti, Rodrigo Pinheiro Toledo Vianna, Flavia Emília Leite de Lima Ferreira, Maria da Conceição Rodrigues Gonçalves and Maria José de Carvalho Costa

    Citation: Nutrition & Metabolism 2018 15:49

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  48. Content type: Research

    To examine the impact of changes in all lipid measures including total cholesterol (TC), log-transformed triglycerides (Ln-TG), high density lipoprotein cholesterol (HDL-C), low density lipoprotein cholesterol...

    Authors: Pegah Khaloo, Mitra Hasheminia, Maryam Tohidi, Hengameh Abdi, Mohammad Ali Mansournia, Fereidoun Azizi and Farzad Hadaegh

    Citation: Nutrition & Metabolism 2018 15:50

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  49. Content type: Research

    Obesity has been identified as a major risk factor for a large number of chronic diseases. Understanding factors related to adolescent obesity is critical for prevention of chronic diseases. The associations b...

    Authors: Hao Wang, Ruying Hu, Huaidong Du, Bragg Fiona, Jieming Zhong and Min Yu

    Citation: Nutrition & Metabolism 2018 15:48

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