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  1. Research

    Phenylketonuria patients’ and their parents’ knowledge and attitudes to the daily diet - multi-centre study

    The aim of the study was to assess both patients’ and their parents’ knowledge of phenylketonuria (PKU) treatment and compliance with PKU diet.

    Ewa Witalis, Bozena Mikoluc, Radoslaw Motkowski, Jolanta Sawicka-Powierza, Agnieszka Chrobot, Bozena Didycz, Agata Lange, Renata Mozrzymas, Andrzej Milanowski, Maria Nowacka, Mariola Piotrowska-Depta, Hanna Romanowska, Ewa Starostecka, Jolanta Wierzba, Magdalena Skorniewska, Barbara Iwona Wojcicka-Bartlomiejczyk…

    Nutrition & Metabolism 2017 14:57

    Published on: 17 August 2017

  2. Research

    Recombinant SFRP5 protein significantly alleviated intrahepatic inflammation of nonalcoholic steatohepatitis

    Secreted frizzled-related protein 5 (SFRP5) is an anti-inflammatory adipokine modulating metabolism dysfunction. This study aims to observe the effect of recombinant SFRP5 protein on nonalcoholic steatohepatit...

    Lili Chen, Xiaolong Zhao, Guangjun Liang, Jiuru Sun, Zhifeng Lin, Renming Hu, Peili Chen, Zhaoyun Zhang, Linuo Zhou and Yiming Li

    Nutrition & Metabolism 2017 14:56

    Published on: 15 August 2017

  3. Research

    Circulating zinc-α2-glycoprotein levels are low in newly diagnosed patients with metabolic syndrome and correlate with adiponectin

    Zinc-α2-glycoprotein (ZAG) is a novel adipokine that reduces insulin resistance, protecting against type 2 diabetes. However, past studies have been contradictory. This cross-sectional study aims to investigat...

    Lu Lei, Kejia Li, Ling Li, Xia Fang, Tingting Zhou, Cheng Zhang, Yong Luo, Hua Liu, Xiaoqiang Li, Hongting Zheng, Lin Zhang, Gangyi Yang and Lin Gao

    Nutrition & Metabolism 2017 14:53

    Published on: 14 August 2017

  4. Research

    Effects of a liquid high-fat meal on postprandial lipid metabolism in type 2 diabetic patients with abdominal obesity

    Postprandial lipemia and lipoprotein lipase (LPL) activity play crucial roles in the pathogenesis of accelerated atherosclerosis. This study aimed to evaluate the postprandial lipid metabolism after the ingest...

    Feng Wang, Huixia Lu, Fukang Liu, Huizhen Cai, Zhixiu Song, Fei Guo, Yulan Xie, Guofang Shu and Guiju Sun

    Nutrition & Metabolism 2017 14:54

    Published on: 14 August 2017

  5. Research

    DHA increases adiponectin expression more effectively than EPA at relative low concentrations by regulating PPARγ and its phosphorylation at Ser273 in 3T3-L1 adipocytes

    Enhancing circulating adiponectin is considered as a potential approach for the prevention and treatment of non-communicable diseases (NCDs). Docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA) were rep...

    Jia Song, Cheng Li, Yushan Lv, Yi Zhang, William Kwame Amakye and Limei Mao

    Nutrition & Metabolism 2017 14:52

    Published on: 11 August 2017

  6. Research

    Season and vitamin D status are independently associated with glucose homeostasis in pregnancy

    Vitamin D status and season are intrinsically linked, and both have been proposed to be associated with glucose homeostasis in pregnancy, with conflicting results. We aimed to determine if exposure to winter a...

    Eileen C. O’Brien, Elizabeth J. O’Sullivan, Mark T. Kilbane, Aisling A. Geraghty, Malachi J. McKenna and Fionnuala M. McAuliffe

    Nutrition & Metabolism 2017 14:50

    Published on: 2 August 2017

  7. Research

    Almonds ameliorate glycemic control in Chinese patients with better controlled type 2 diabetes: a randomized, crossover, controlled feeding trial

    Almonds can decrease glycemic index of co-consumed foods and are a rich source for oleic acid and α-tocopherol. The aim of the randomized, crossover, controlled feeding trial was to examine whether as compared...

    Chiao-Ming Chen, Jen-Fang Liu, Sing-Chung Li, Chen-Ling Huang, An-Tsz Hsirh, Shuen-Fu Weng, Mei-Ling Chang, Hung-Ta Li, Emily Mohn and C-Y. Oliver Chen

    Nutrition & Metabolism 2017 14:51

    Published on: 2 August 2017

  8. Research

    eIF2α phosphorylation is required to prevent hepatocyte death and liver fibrosis in mice challenged with a high fructose diet

    Dietary fructose can rapidly cause fatty liver in animals through de novo lipogenesis (DNL) and contribute to the development and severity of nonalcoholic fatty liver disease (NAFLD). In response to diverse ce...

    Woo-Gyun Choi, Jaeseok Han, Ji-Hyeon Kim, Mi-Jeong Kim, Jae-Woo Park, Benbo Song, Hee-Jeong Cha, Hye-Seon Choi, Hun-Taeg Chung, In-Kyu Lee, Tae-Sik Park, Maria Hatzoglou, Hueng-Sik Choi, Hyun Ju Yoo, Randal J. Kaufman and Sung Hoon Back

    Nutrition & Metabolism 2017 14:48

    Published on: 1 August 2017

  9. Review

    Hyperglycemia-induced oxidative stress and heart disease-cardioprotective effects of rooibos flavonoids and phenylpyruvic acid-2-O-β-D-glucoside

    Diabetic patients are at an increased risk of developing heart failure when compared to their non-diabetic counter parts. Accumulative evidence suggests chronic hyperglycemia to be central in the development o...

    Phiwayinkosi V. Dludla, Elizabeth Joubert, Christo J.F. Muller, Johan Louw and Rabia Johnson

    Nutrition & Metabolism 2017 14:45

    Published on: 10 July 2017

  10. Research

    Positive association between musclin and insulin resistance in obesity: evidence of a human study and an animal experiment

    Musclin is a novel skeletal muscle-derived secretory factor considered to be a potent regulator of the glucose metabolism and therefore may contribute to the pathogenesis of obesity and insulin resistance (IR).

    Wen-Jia Chen, Yue Liu, Yu-Bin Sui, Hong-Tao Yang, Jin-Rui Chang, Chao-Shu Tang, Yong-Fen Qi, Jing Zhang and Xin-Hua Yin

    Nutrition & Metabolism 2017 14:46

    Published on: 10 July 2017

  11. Research

    Free fatty acids and cardiovascular outcome: a Chinese cohort study on stable coronary artery disease

    Studies have revealed that plasma level of free fatty acids (FFAs) is related to cardiovascular disease. However, the role of FFAs in clinical outcomes of stable coronary artery disease (SCAD) has been less ev...

    Hui-Wen Zhang, Xi Zhao, Yuan-Lin Guo, Cheng-Gang Zhu, Na-Qiong Wu, Jing Sun, Geng Liu, Qian Dong and Jian-Jun Li

    Nutrition & Metabolism 2017 14:41

    Published on: 26 June 2017

  12. Research

    Supramolecular structure of dietary fat in early life modulates expression of markers for mitochondrial content and capacity in adipose tissue of adult mice

    Previous studies have shown that early life nutrition can modulate the development of white adipose tissue and thereby affect the risk on obesity and metabolic disease later in life. For instance, postnatal fe...

    Andrea Kodde, Eline M. van der Beek, Esther Phielix, Eefje Engels, Lidewij Schipper and Annemarie Oosting

    Nutrition & Metabolism 2017 14:37

    Published on: 12 June 2017

  13. Research

    The role of a dairy fraction rich in milk fat globule membrane in the suppression of postprandial inflammatory markers and bone turnover in obese and overweight adults: an exploratory study

    Inflammation is associated with increased bone resorption; the role of inflammation in postprandial bone turnover has not been explored. Consumption of milk fat globule membrane (MFGM) reduces inflammation in ...

    Tara S. Rogers, Elieke Demmer, Nancy Rivera, Erik R. Gertz, J. Bruce German, Jennifer T. Smilowitz, Angela M. Zivkovic and Marta D. Van Loan

    Nutrition & Metabolism 2017 14:36

    Published on: 17 May 2017

  14. Research

    Essential amino acid ingestion alters expression of genes associated with amino acid sensing, transport, and mTORC1 regulation in human skeletal muscle

    Amino acid availability stimulates protein synthesis via the mTORC1 (mechanistic target of rapamycin complex 1) signaling pathway. In response to an increase in cellular amino acid availability, translocation ...

    Ted G. Graber, Michael S. Borack, Paul T. Reidy, Elena Volpi and Blake B. Rasmussen

    Nutrition & Metabolism 2017 14:35

    Published on: 11 May 2017

  15. Research

    Association of adipokines with blood pressure, arterial elasticity and cardiac markers in dialysis patients: cross-sectional analysis of baseline data from a cohort study

    Adipokines are a set of cytokines secreted by white adipose tissue that have been suggested to be involved in the development of cardiovascular diseases. We aimed to evaluate the cross-sectional associations o...

    Wenjin Liu, Lei Jiang, Jianping Chen, Chaoqing Gao, Jianmei Zhou, Jiajun Zhou, Youwei Bai, Hong Chu, Wei Fan, Liang Wang, Zhuxing Sun, Xiurong Li and Junwei Yang

    Nutrition & Metabolism 2017 14:34

    Published on: 10 May 2017

  16. Research

    Eicosapentaenoic acid shows anti-inflammatory effect via GPR120 in 3T3-L1 adipocytes and attenuates adipose tissue inflammation in diet-induced obese mice

    Saturated fatty acids have been shown to cause insulin resistance and low-grade chronic inflammation, whereas unsaturated fatty acids suppress inflammation via G-protein coupled receptor 120 (GPR120) in macrop...

    Hodaka Yamada, Tomio Umemoto, Masafumi Kakei, Shin-ichi Momomura, Masanobu Kawakami, San-e Ishikawa and Kazuo Hara

    Nutrition & Metabolism 2017 14:33

    Published on: 8 May 2017

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