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Table 5 Effect of LC-MUFAs on fatty acid composition (%) in plasma and liver in KK-A y mice

From: Dietary supplementation with long-chain monounsaturated fatty acids attenuates obesity-related metabolic dysfunction and increases expression of PPAR gamma in adipose tissue in type 2 diabetic KK-Ay mice

Fatty acid

Plasma

Liver

Soybean oil diet (control)

LC-MUFA diet

Soybean oil diet (control)

LC-MUFA diet

14:0

0.19 ± 0.04

0.30 ± 0.02*

0.38 ± 0.06

0.56 ± 0.02*

16:0

21.68 ± 0.59

20.34 ± 0.49

22.11 ± 0.32

23.62 ± 0.60*

18:0

12.05 ± 0.69

9.31 ± 0.41**

6.12 ± 0.34

4.36 ± 0.24***

20:0

0.35 ± 0.04

0.35 ± 0.01

0.41 ± 0.02

0.39 ± 0.02

SFA

34.26 ± 0.96

30.31 ± 0.73**

29.02 ± 0.38

28.94 ± 0.61

16:1 n-7

1.57 ± 0.26

2.61 ± 0.22**

3.51 ± 0.20

5.14 ± 0.39**

18:1 n-9

12.21 ± 1.62

17.84 ± 0.79**

28.74 ± 1.11

36.23 ± 1.01***

18:1 n-7

2.41 ± 0.19

2.99 ± 0.13*

3.68 ± 0.19

4.67 ± 0.22**

20:1 n-11

ND

0.73 ± 0.06***

ND

1.27 ± 0.07***

20:1 n-9

0.41 ± 0.05

0.74 ± 0.02***

0.78 ± 0.03

0.91 ± 0.04*

22:1 n-11

ND

0.48 ± 0.09**

ND

0.36 ± 0.03***

22:1 n-9

0.01 ± 0.01

0.03 ± 0.01

0.12 ± 0.01

0.17 ± 0.01**

LC-MUFA

0.42 ± 0.06

1.97 ± 0.18***

0.90 ± 0.03

2.70 ± 0.13***

MUFA

16.61 ± 2.06

25.39 ± 0.92**

36.83 ± 1.37

48.74 ± 0.98***

18:2 n-6

26.71 ± 1.11

22.37 ± 0.47**

18.43 ± 0.73

10.01 ± 0.46***

18:3 n-6

0.27 ± 0.03

0.32 ± 0.01

0.20 ± 0.01

0.13 ± 0.01***

20:2 n-6

0.32 ± 0.04

0.26 ± 0.01

0.25 ± 0.03

0.12 ± 0.01***

20:3 n-6

1.35 ± 0.09

1.52 ± 0.07

0.62 ± 0.03

0.48 ± 0.03**

20:4 n-6

9.98 ± 1.17

6.61 ± 0.44***

5.11 ± 2.71

2.71 ± 0.24***

n-6 PUFA

38.62 ± 1.71

31.08 ± 0.56**

24.61 ± 0.97

13.44 ± 0.57***

18:3 n-3

0.89 ± 0.06

0.53 ± 0.05***

1.10 ± 0.04

0.41 ± 0.03***

20:5 n-3

0.62 ± 0.07

1.39 ± 0.04***

0.32 ± 0.03

0.39 ± 0.03

22:5 n-3

0.42 ± 0.06

0.54 ± 0.02

0.10 ± 0.01

0.19 ± 0.02**

22:6 n-3

5.42 ± 0.37

6.08 ± 0.32

3.33 ± 0.20

2.69 ± 0.20*

n-3 PUFA

7.32 ± 0.28

8.54 ± 0.27**

4.85 ± 0.25

3.67 ± 0.22**

n-3/n-6

0.19 ± 0.01

0.27 ± 0.01***

0.20 ± 0.01

0.27 ± 0.01***

  1. Each value represents the mean ± SE (n = 10). ND: Not detected; WAT: white adipose tissue; SFA: saturated fatty acids; MUFA: monounsaturated fatty acids; LC-MUFA: long-chain monounsaturated fatty acids (C20:1 and C22:1 isomers combined); PUFA: polyunsaturated fatty acids; * p < 0.05; ** p < 0.01; *** p < 0.001 compared with the control group.