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Table 5 Estimates of D9D activity according to genotype for each SCD1 SNP in Caucasians

From: Plasma concentration of cis 9trans 11 CLA in males and females is influenced by SCD1 genetic variations and hormonal contraceptives: a cross-sectional study

 

[18:2c9t11/18:1 t11] in males

[18:2c9t11/18:1 t11] in females

MM

Mm

mm

P-value

MM

Mm

mm

P-value

rs10883463

1.077 ± 0.036a

0.769 ± 0.048b

-

<0.01*

1.206 ± 0.036

1.244 ± 0.061

1.505 ± 0.170

0.75

rs17669878

1.079 ± 0.070

0.977 ± 0.040

1.064 ± 0.076

0.23

1.248 ± 0.041

1.195 ± 0.050

1.207 ± 0.074

0.72

rs2060792

1.015 ± 0.037

0.998 ± 0.061

1.215 ± 0.179

0.62

1.251 ± 0.053

1.175 ± 0.036

1.229 ± 0.088

0.58

rs3071

1.037 ± 0.052

1.024 ± 0.046

0.913 ± 0.051

0.78

1.202 ± 0.031

1.224 ± 0.059

1.238 ± 0.105

0.87

rs3793766

1.003 ± 0.036

1.083 ± 0.078

1.200

0.59

1.217 ± 0.035

1.209 ± 0.057

1.084 ± 0.391

0.94

rs3793767

0.939 ± 0.042

1.043 ± 0.051

1.111 ± 0.097

0.25

1.178 ± 0.043

1.252 ± 0.052

1.200 ± 0.054

0.81

rs490726

1.073 ± 0.042

0.960 ± 0.053

0.856 ± 0.344

0.23

1.215 ± 0.041

1.217 ± 0.046

1.229 ± 0.107

0.99

rs522951

1.044 ± 0.046

1.011 ± 0.050

1.019 ± 0.081

0.78

1.125 ± 0.055

1.252 ± 0.049

1.237 ± 0.048

0.42

rs569184

1.010 ± 0.036

1.060 ± 0.079

1.200

0.72

1.223 ± 0.035

1.198 ± 0.054

0.637 ± 0.055

0.38

rs575338

1.024 ± 0.042

1.024 ± 0.045

1.003 ± 0.155

0.99

1.193 ± 0.029

1.291 ± 0.098

1.188 ± 0.084

0.44

  1. Results of analysis of 10 SNPs from SCD1 for associations with D9D activity index [182c9t11:181 t11]. Different letters (a or b) denote values that are significantly different between groups. P-values were determined using linear regression models which were adjusted for BMI, age, % of Total Energy from Dietary Fat and physical activity. Caucasian Males: n = 113; Caucasian females: n = 298; Asian Males: n = 98; Asian Females: n = 277. Abbreviations: D9D, delat-9-desaturase; M, major; m, minor; ‘-’ indicates that no subjects with this genotype were present in this population.