Characterization of the plasma metabolomic changes induced by BaP. 2a. CMPG_PCA score plot revealed that T0 and T21 groups were clearly separated along PC1 and PC2; 2b. CMPG_PCA corresponding loading plot indicating the regions of the spectra that are responsible for the group separation; 2c. OPLS_S-Plot used to identify possible metabolites that correlate the metabolomic profile to HDL-C concentration; 2d. Two-dimensional PLS-DA score plot showing group discrimination based on treatment received. Notes: T0, high fat diet and water; T21, high fat diet and BaP for 21 days. N = 8 hamsters per group. Abbreviations: Biologically active fraction of ProAlgaZyme, BaP; Carr-Purcell-Meiboom-Gill, CPMG; orthogonal projections to latent structures, OPSL; principal component, PC; principal components analysis, PCA; partial least squares-discriminant analysis, PLS-DA.