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Table 1 Effect of ATP supplementation on muscle strength and power in participants performing a 12 week weight training regimen. a

From: Effects of oral adenosine-5′-triphosphate supplementation on athletic performance, skeletal muscle hypertrophy and recovery in resistance-trained men

  Week of Study  
  0 4 8 9 10 12 p-valueb
Squat, kg        
Placebo 145.2 ± 10.2 151.6 ± 11.0 156.4 ± 11.6 150.7 ± 10.4 147.2 ± 10.7 151.3 ± 10.3  
ATP 146.1 ± 5.8 155.2 ± 7.7 160.7 ± 7.6 159.0 ± 6.1# 158.6 ± 6.9# 165.3 ± 8.3# <0.001
Bench Press, kg        
Placebo 115.2 ± 9.4 119.3 ± 9.4 121..4 ± 9.3 113.4 ± 7.2 115.7 ± 8.0 119.3 ± 8.7  
ATP 117.2 ± 5.5 122.1 ± 5.0 124.5 ± 5.2 120.0 ± 4.8 121.2 ± 5.5 124.2 ± 5.4 0.65
Deadlift, kg        
Placebo 169.8 ± 11.0 177.0 ± 10.7 182.5 ± 10.7 173.2 ± 10.8 174.8 ± 8.1 182.0 ± 9.2  
ATP 176.2 ± 4.9 189.2 ± 5.9 200.3 ± 7.4# 193.4 ± 6.4# 193.8 ± 8.3# 205.2 ± 6.9# 0.002
Total Strength, kg       
Placebo 430.2 ± 28.1 448.0 ± 28.9 460.2 ± 29.6 437.3 ± 26.1 437.6 ± 25.1 452.6 ± 25.9  
ATP 439.4 ± 14.9 466.5 ± 17.1 485.6 ± 18.1# 472.4 ± 15.2# 473.6 ± 18.3# 494.7 ± 17.9# <0.001
Wingate Peak Power, Watts       
Placebo 882.2 ± 54.1 930.3 ± 55.7 985.3 ± 64.7 922.9 ± 61.9 939.9 ± 65.7 977.4 ± 66.5  
ATP 882.8 ± 27.0 960.9 ± 36.1 1003.5 ± 40.4 964.2 ± 38.0 974.7 ± 39.8 1011.9 ± 42.4 0.48
Vertical Jump power, Watts       
Placebo 5318 ± 410 5711 ± 439 5918 ± 443 5697 ± 436 5626 ± 431 5932 ± 452  
ATP 5185 ± 203 5618 ± 213 5954 ± 202# 5838 ± 218# 5827 ± 208# 5981 ± 207# <0.001
  1. aMean ± SEM for n = 11 ATP (400 mg ATP/d taken 30 min prior to exercise) and n = 10 placebo supplemented participants.
  2. bProbability of treatment by time difference between the placebo and the ATP treatments over the 12-week study. The mixed model ANOVA in SAS® was used with the main effects of treatment, time and treatment by time, with the value for week 0 used as a covariate.
  3. #Significantly different than corresponding placebo, t-test (p < 0.05).