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Figure 6 | Nutrition & Metabolism

Figure 6

From: Zerumbone, a tropical ginger sesquiterpene, ameliorates streptozotocin-induced diabetic nephropathy in rats by reducing the hyperglycemia-induced inflammatory response

Figure 6

The possible action mechanisms of zerumbone on the amelioration of DN in STZ-diabetic rats. Hyperglycemia induced p38 activation to augment the expression of ICAM-1and MCP-1, thereby enhanced the infiltration of monocytes and/or macrophages. The activated macrophages promoted the expression of inflammatory cytokines including TNFα, IL-1 and IL-6. All of the above abnormalities were reversed by zerumbone treatment. Zerumbone also decreased the expression of fibronectin, by reducing the TGF-β1 expression in the diabetic kidney.

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Nutrition & Metabolism

ISSN: 1743-7075

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