Normal rats | STZ-diabetic rats | ||||
---|---|---|---|---|---|
Vehicle | Vehicle | ZER 20 | ZER 40 | RGZ | |
Body weight (BW) (g/rat) | 402.94 ± 16.88d | 262.38 ± 16.14b | 287.74 ± 15.92b,c | 318.42 ± 17.64a,c | 335.18 ± 18.10a,d |
Kidney weight (KW) (g) | 1.58 ± 0.32d | 2.84 ± 0.22b | 2.47 ± 0.35b | 2.26 ± 0.27a,c | 1.96 ± 0.29d |
KW/BW ratio (%) | 0.32 ± 0.06d | 1.08 ± 0.11b | 0.86 ± 0.07b | 0.71 ± 0.08b,c | 0.58 ± 0.03a,d |
Plasma glucose (mg/dl) | 95.72 ± 6.38d | 445.02 ± 16.43b | 361.72 ± 17.14b,c | 317.48 ± 15.31b,c | 301.62 ± 16.23b,c |
HbA1c (%) | 4.88 ± 0.92d | 14.57 ± 1.17b | 12.48 ± 1.26b | 11.21 ± 1.09b | 10.76 ± 0.89b,c |
Plasma insulin (μU/ml) | 25.43 ± 0.51d | 0.27 ± 0.14 b | 0.31 ± 0.12b | 0.35 ± 0.19b | 0.41 ± 0.21b |
24-h urine volume (ml/day) | 9.15 ± 2.14d | 27.86 ± 3.17b | 22.29 ± 3.08b | 18.02 ± 3.72a,c | 15.68 ± 2.83a,c |
24-h urine protein (mg/day) | 6.81 ± 3.26d | 29.24 ± 5.71b | 20.47 ± 4.82b | 15.28 ± 3.62a,d | 11.42 ± 4.74a,d |
Scr (μmol/l) | 35.13 ± 5.43d | 87.87 ± 8.21b | 72.89 ± 7.21b | 64.14 ± 6.23b,c | 58.24 ± 5.77b,c |
BUN (mmol/l) | 6.85 ± 1.32c | 19.81 ± 1.84b | 16.51 ± 1.75b | 14.38 ± 1.76b,c | 10.23 ± 1.56a,c |
Ccr (ml/min) | 4.26 ± 0.59d | 1.84 ± 0.64b | 2.21 ± 0.46b | 3.02 ± 0.47a,c | 3.46 ± 0.52d |