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Table 2 Renal levels of cytokines in experimental animals at the end of the eight-week treatment

From: Zerumbone, a tropical ginger sesquiterpene, ameliorates streptozotocin-induced diabetic nephropathy in rats by reducing the hyperglycemia-induced inflammatory response

Cytokines

Normal rats

STZ-diabetic rats

 

Vehicle

Vehicle

ZER 20

ZER 40

RGZ

TNF-α (pg/mg protein)

72.04 ± 8.26d

169.35 ± 9.74b

134.30 ± 10.33b,c

107.19 ± 8.71b,d

96.47 ± 7.36a,d

IL-1β (pg/mg protein)

23.37 ± 4.17d

62.78 ± 5.07b

42.26 ± 2.97b,c

33.21 ± 3.81b,c

29.88 ± 3.74b,c

IL-6 (pg/mg protein)

55.73 ± 8.74d

164.27 ± 12.32b

130.25 ± 9.23b,c

109.17 ± 10.51b,c

87.52 ± 5.13b,c

  1. STZ-diabetic rats were dosed by oral gavage once per day for eight weeks with 5 mg/kg/day rosiglitazone (RGZ), 20 mg/kg/day zerumbone (ZER 20), 40 mg/kg/day zerumbone (ZER 40). Normal or STZ-diabetic rats receiving vehicle treatment were given the same volume of vehicle (distilled water) used to dissolve test medications. Values (mean ± SD) were obtained for each group of 8 animals.
  2. ap < 0.05 and bp < 0.01 compared to the values of vehicle-treated normal rats.
  3. cp < 0.05 and dp < 0.01 compared to the values of vehicle-treated STZ-diabetic rats, respectively.
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Nutrition & Metabolism

ISSN: 1743-7075

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