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Figure 1 | Nutrition & Metabolism

Figure 1

From: Oleanolic acid attenuates renal fibrosis in mice with unilateral ureteral obstruction via facilitating nuclear translocation of Nrf2

Figure 1

Effects of oleanolic acid (OA) on renal morphological changes in unilateral ureteral obstruction (UUO). (A) Representative photographs assessing renal tubular injury (H&E, x200), interstitial fibrosis (Masson trichrome, x200), immunohistochemical staining for the infiltration of F4/80-positive cells (x400) and TUNEL staining (x400). Black arrows indicate TUNEL-positive cells (brown color). (B) Renal tubular injury index. (C) Semiquantitative analysis of interstitial fibrosis. (D) Number of F4/80-positive cells. (E) Number of TUNEL-positive cells. Sh, sham; UC3, UUO-control day 3; UOA3, UUO-oleanolic acid day 3; UC7, UUO-control day 7; UOA7, UUO-oleanolic acid day 7; * P < 0.05 versus UUO-control day 3 group; †P < 0.05 versus UUO-control day 7 group.

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Nutrition & Metabolism

ISSN: 1743-7075

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