Fish oil and krill oil supplementations differentially regulate lipid catabolic and synthetic pathways in mice

Nutrition & Metabolism

Table 9 Liver enzyme activities

Diet	CPT1 activity	CPT1 activity	ACOX activity	FAS activity
	nmol/mg/min - 15μM Malonyl-CoA	nmol/mg/min + 15μM Malonyl-CoA	nmol/mg/min	nmol/mg/min
High fat	2.35 (1.83–3.74)	1.24 (1.05–4.41)	16.8 (14.4–30.6)	0.31 (0.24–0.38)
FO	3.42 (2.22–3.73)	2.10 (1.61–2.20)	43.8 (33.3–54.7)^a**	0.57 (0.36–0.63)^c***
KO	2.50 (1.84–3.08)	1.49 (1.28–2.15)	22.4 (16.8–39.4)	0.20 (0.12–0.22)
p (K-W)	0.337	0.120	0.005	0.001

Acyl-CoA oxidase (ACOX), fatty acid synthase (FAS) and carnitine palmitoyltransferase 1 (CPT1) activities were measured as described in Materials and Methods. CPT1 activity was measured with and without the addition of 15 μM malonyl-CoA. Data shown as median and range. High fat (n = 6), FO (n = 5) and KO (n = 6). a = HF vs FO, c = FO vs KO. ^**= p <0.01 and ^***= p <0.001. K-W, p indicates the p -value with the Kruskal-Wallace test. FO; fish oil, KO; Krill oil.

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