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Table 4 Primary and secondary outcomes comparison between groups at baseline and after 21 days on the prescribed diets

From: The effect of the macrobiotic Ma-Pi 2 diet vs. the recommended diet in the management of type 2 diabetes: the randomized controlled MADIAB trial

Median [1st-3rdquartiles] Ma-Pi 2 diet (n = 25) Control diet (n = 26)
Baseline T21 Absolute change Percent change Baseline T21 Absolute change Percent change p value*
Fasting blood glucose (mg/dl) 129 (111; 149) 95 (91; 100) 34 (21; 44) 26.2 (18.7; 34.1) 126 (112; 150) 110 (99; 115) 22.8 (8.1; 44.6) 16.9 (6.9; 30.1) 0.073
Post prandial blood glucose (mg/dl) 134 (112; 179) 100 (94; 106) 34 (18; 75.5) 23.1 (15.9; 42.9) 144 (128; 210) 127 (108; 151) 15.3 (−1.6; 58.6) 8.7 (−1.9; 50.3) 0.035
HbA 1c (%) 6.7 (6.2; 7.7) 6.3 (5.9; 7) 0.4 (0.2; 0.6) 6.2 (3.3; 8.3) 6.8 (6.4; 7.1) 6.6 (6.2; 7) 0.2 (0.1; 0.4) 2.2 (1.5; 5) 0.002
HOMA-IR 3.1 (1.2; 4.1) 0.98 (0.61; 1.98) 1.3 (0.1; 2.9) 51.4 (11.7; 78.3) 3.3 (0.9; 4.6) 1.6 (1.2; 2.4) 1.4 (−0.2; 2.3) 40.4 (−21.9; 62) 0.142
Total cholesterol (mg/dl) 176 (155; 217) 120 (102; 138) 57 (40; 65) 32 (23.8; 38.6) 180.5 (150.2; 210.8) 154 (133; 185) 24 (16; 43) 12.3 (9.9; 23) < 0.001
LDL cholesterol (mg/dl) 102 (84; 133) 62 (39; 69) 45 (33; 58) 47.9 (33.5; 53.6) 101.5 (84.8; 123.5) 81 (66; 105) 20 (12.3; 31.3) 19.7 (13.5; 27.8) < 0.001
HDL cholesterol (mg/dl) 46 (38; 52) 42 (36; 51) 4 (−1; 8) 7.5 (−2.2; 17.1) 48.5 (43; 55.8) 47 (40; 56) 0.5 (−2; 6.8) 0.9 (−4.4; 11.5) 0.283
LDL/HDL ratio 2.4 (2; 3) 1.3 (0.9; 2.4) 0.9 (0.5; 1.3) 38.5 (29.3; 49.9) 2 (1.8; 2.6) 1.8 (1.3; 2.4) 0.4 (0.1; 0.7) 17.2 (5.9; 29.5) < 0.001
BMI (kg/m 2 ) 31.3 (29.9; 36.8) 29.5 (28.2; 34.6) 2 (1.8; 2.4) 5.9 (5.4; 6.9) 32 (28.2; 35.9) 30.8 (27.3; 34.6) 1 (0.7; 1.3) 2.9 (2.4; 4.1) < 0.001
Weight (kg) 81.1 (75.6; 99.1) 77 (70; 94) 5.5 (4.4; 6) 6.3 (5.6; 7.2) 87 (79; 103.9) 83 (75; 100) 2.8 (2; 3.6) 2.9 (2.4; 4.2) < 0.001
Waist circumference (cm) 107.6 (97.9; 114.7) 103 (96; 112) 4.2 (1.4; 6.5) 3.9 (1.6; 5.3) 105.2 (101.6; 117.5) 103 (101; 113) 2.3 (0.9; 4) 1.9 (0.9; 2.9) 0.046
Hip circumference (cm) 108.7 (102.5; 23.8) 105 (99; 120) 3.4 (2; 5.2) 3.1 (1.8; 4) 109.7 (102.6; 118.4) 108 (101; 118.4) 1.8 (1; 2.5) 1.6 (0.8; 2.4) 0.006
  1. Legend: *P-value by Wilcoxon rank-sum test are referred to percent changes between the two treatment groups.