Figure 2From: Transcriptional regulation of lipid metabolism by fatty acids: a key determinant of pancreatic β-cell functionOverview of PPAR activation and effects. FFA (eg. oleic acid) interact with PPAR, which dimerize with retinoid X receptor (RXR) and translocate to the nucleus where the complex interacts with PPRE to activate gene transcription. The general effects of transcriptional activation of PPARα, PPARδ and PPARγ are shown on the right of the figure.Back to article page