Age and kidney function are the primary correlates of fasting plasma total homocysteine levels in non-diabetic and diabetic adults. Results from the 1999–2002 National Health and Nutrition Examination Survey

Table 2 Relationships between total plasma homocysteine and select physiologic variables, by fasting glucose status, among 3,485 U.S. adults (≥ 20y) with no self-reported diabetes.

Group	Age	Glucose	HbA_1c	Insulin	BMI	SBP	TC	Folate	B₁₂	S_Cr	C_Cr
Total	0.41*	0.12*	0.10*	-0.00	-0.01	0.28*	0.11*	-0.10*	-0.25*	0.35*	-0.38*
NFG	0.38*	0.11*	0.12*	-0.05‡	-0.02	0.30*	0.14*	-0.15*	-0.24*	0.34*	-0.35*
IFG	0.38*	0.15*	0.07‡	-0.06	-0.07‡	0.19*	-0.01	-0.05	-0.26*	0.32*	-0.42*
DFG	0.44*	-0.14	-0.19‡	-0.21‡	-0.19‡	0.13	0.05	0.15	-0.28†	0.55*	-0.46*

Data are from the combined 1999–2000 and 2001–2002 National Health and Nutrition Examination Surveys. Non-standard abbreviations are NFG, normal fasting glucose, IFG, impaired fasting glucose, DFG, provisional diagnosis of diabetes, SBP, systolic blood pressure, TC, total lipoprotein cholesterol, S_Cr, serum creatinine, and C_Cr, estimated creatinine clearance. Values are Pearson correlation coefficients (r) using log transformed total homocysteine (log tHcy) as the dependent variable.
*P < 0.0001
†P < 0.01
‡P < 0.05

ISSN: 1743-7075