From: The role of glucocorticoid action in the pathophysiology of the Metabolic Syndrome
Gene Names | Function | Regulation | Reference |
---|---|---|---|
Glutamine synthetase | Amino acid metabolism | Up | 42 |
TAT | Amino acid catabolism | Up | 43, 44 |
Tryptophan oxygenase | Amino acid catabolism | Up | 45 |
PEPCK (liver) | Gluconeogenesis | Up | 46 |
G6Pase | Gluconeogenesis | Up | 47, 48 |
Angiotensinogen | Precursor of angiotensin I; vasoconstriction, electrolyte balance, etc. | Up | 49 |
Leptin | Energy metabolism | Up | 50 |
VLDLR | Lipoprotein metabolism | Up | 51 |
PEPCK (adipose) | Glyceroneogenesis | Down | 52 |
aP2 | Intracellular lipid shuttling and metabolism | Up | 53 |
GLUT4 | Glucose transport | Up | 53 |
HSL | Lipolysis | Up | 53 |
LPL | Lipid metabolism | Up | 53 |
TNF-α | Inflammation and apoptosis | Down | 53 |
Osteocalcin | Marker for mature osteoblasts | Down | 54, 55 |
CRH | Stress mediated/feedback hormone release | Down | 56 |
POMC | Precursor of pituitary hormones | Down | 57, 58 |
Prolactin | Hormone critical for reproduction | Down | 59 |
Proliferin | Angiogenesis | Down | 60, 61 |
Glycoprotein hormone α-subunit | Common subunit of gonadotropin hormones | Down | 62, 63 |
IL-6 | Proinflammatory cytokine | Down | 64 |
IL-8 | Proinflammatory cytokine | Down | 65 |
Collagenase | Matrix protease | Down | 66 |
ICAM-1 | Inflammatory response | Down | 39 |