Skip to main content

Advertisement

Table 1 Metabolic alterations in PEPCK-C-/- mice at two days of age.

From: Phosphoenolpyruvate carboxykinase and the critical role of cataplerosis in the control of hepatic metabolism

Body composition PEPCK-C+/+ (n) PEPCK-C-/- (n)
% Water 80.3 ± 0.30 3 79.26 ± 0.22 3
% Fat 3.48 ± 0.36 3 1.85 ± 0.57 3
% Lean Mass 16.42 ± 0.63 3 18.88 ± 0.78 3
Metabolites in liver     
Triglyceride (μmoles/g) 4.17 ± 1.00 5 9.58 ± 1.75 5
Lactate (μmoles/g) 0.19 ± 0.02 3 0.37 ± 0.09 3
Malate (μmoles/g) 0.24 ± 0.05 3 2.84 ± 1.58 3
Metabolites in plasma     
Triglyceride (mg/dl) 23.7 ± 6.3 3 36.3 ± 21.5 2
Ammonia (μmoles/ml) 0.14 ± 0.02 5 0.45 ± 0.28 4
BUN (mg/dl) 29.0 ± 7.0 2 65.5 ± 28.5 2
Lactate (μmoles/ml) 0.28 ± 0.13 3 0.72 ± 0.47 3
β-Hydoxybutyrate (μmoles/ml) 5.83 ± 0.21 3 17.95 ± 0.70 3
  1. The values are expressed as the mean ± S.E. for the number of animals shown in parenthesis