Table 1 Metabolic alterations in PEPCK-C-/- mice at two days of age.
Body composition | PEPCK-C+/+ | (n) | PEPCK-C-/- | (n) |
|---|---|---|---|---|
% Water | 80.3 ± 0.30 | 3 | 79.26 ± 0.22 | 3 |
% Fat | 3.48 ± 0.36 | 3 | 1.85 ± 0.57 | 3 |
% Lean Mass | 16.42 ± 0.63 | 3 | 18.88 ± 0.78 | 3 |
Metabolites in liver | ||||
Triglyceride (μmoles/g) | 4.17 ± 1.00 | 5 | 9.58 ± 1.75 | 5 |
Lactate (μmoles/g) | 0.19 ± 0.02 | 3 | 0.37 ± 0.09 | 3 |
Malate (μmoles/g) | 0.24 ± 0.05 | 3 | 2.84 ± 1.58 | 3 |
Metabolites in plasma | ||||
Triglyceride (mg/dl) | 23.7 ± 6.3 | 3 | 36.3 ± 21.5 | 2 |
Ammonia (μmoles/ml) | 0.14 ± 0.02 | 5 | 0.45 ± 0.28 | 4 |
BUN (mg/dl) | 29.0 ± 7.0 | 2 | 65.5 ± 28.5 | 2 |
Lactate (μmoles/ml) | 0.28 ± 0.13 | 3 | 0.72 ± 0.47 | 3 |
β-Hydoxybutyrate (μmoles/ml) | 5.83 ± 0.21 | 3 | 17.95 ± 0.70 | 3 |