The levels of plasma low density lipoprotein are independent of cholesterol ester transfer protein in fish-oil fed F1B hamsters

Table 1 LDL-lipid composition of hamsters fed with various diets.

LDL-Lipids	Diet	Chol	Low Fat 5%	High Fat 20%	Statistical significance (3 way ANOVA)
					Factor	P value
Total Cholesterol (mmol/l)	FO	-	4.84 ± 0.61	4.57 ± 0.36	DT	0.0001
		+	8.84 ± 2.06	5.10 ± 1.00	DT × DL	0.0020
	MIX	-	1.54 ± 0.32	1.41 ± 0.25	DT × CHOL	0.0007
		+	1.27 ± 0.25	1.63 ± 0.48	DL × CHOL	0.0200
Free Cholesterol (mmol/l)	FO	-	0.45 ± 0.05	1.53 ± 0.46	DL	0.0001
		+	0.69 ± 0.17	1.99 ± 0.45
	MIX	-	0.28 ± 0.10	0.70 ± 0.13
		+	0.38 ± 0.14	0.58 ± 0.15
Cholesterol Ester (mmol/l)	FO	-	4.08 ± 0.43	2.62 ± 0.84	DT	0.0001
		+	8.05 ± 1.96	3.07 ± 1.00	CHOL	0.0001
	MIX	-	0.87 ± 0.30	0.88 ± 0.29	DT × DL	0.0300
		+	0.80 ± 0.17	0.79 ± 0.17	DL × CHOL	0.0004
Triacylglycerol (mmol/l)	FO	-	0.65 ± 0.08	1.62 ± 0.27	DT	0.0001
		+	1.01 ± 0.34	1.53 ± 0.22	DT × DL	0.0001
	MIX	-	0.24 ± 0.03	0.22 ± 0.04	DL × CHOL	0.0200
		+	0.29 ± 0.07	0.17 ± 0.01
Phospholipids (mmol/l)	FO	-	0.69 ± 0.10	0.66 ± 0.11	DT	0.0001
		+	0.98 ± 0.18	0.73 ± 0.10	CHOL	0.03
	MIX	-	0.37 ± 0.07	0.36 ± 0.06	DT × DL	0.03
		+	0.33 ± 0.05	0.36 ± 0.04	DT × CHOL	0.009

FO, fish oil; MIX, MIX diet; Chol, cholesterol; DT, diet type; DL, diet level; CHOL, Cholesterol For details of diets and procedures, see "Materials and methods" section. Animals were fed the indicated diets for 2 weeks. All values represent means ± SD.

ISSN: 1743-7075