Table 2 List of 15 genes and 27 SNPs studied for association with weight loss induced by a low CHO diet.
From: Physiogenomic analysis of weight loss induced by dietary carbohydrate restriction
Gene Family or Pathway | Gene | SNP | N | mac | min | maj | Freq | Gene | Description | Sequence Context |
|---|---|---|---|---|---|---|---|---|---|---|
Lipases | Hepatic lipase | rs936960 | 49 | 7 | A | C | 0.07 | LIPC | lipase, hepatic | CAGAGCACGAGGCTGATTTTC [A/C]ATCCCAGTGTGGGCCACACC |
rs417344 | 50 | 13 | T | C | 0.13 | LIPC | lipase, hepatic | TTTCCTAATTTTGCAGTTGAG [A/G]TTTAAGAGGTTGGGAACTGG | ||
rs6083 | 39 | 28 | A | G | 0.36 | LIPC | lipase, hepatic | GTCTTTCTCCAGATGATGCCA [A/G]TTTTGTGGATGCCATTCATA | ||
Lipoprotein lipase | rs295 | 46 | 15 | A | C | 0.16 | LPL | lipoprotein lipase | GATGCACCTACTAGACACCTA [A/C]TCTGCGCTAGATGGTGGGGG | |
rs328 | 53 | 10 | C | G | 0.09 | LPL | lipoprotein lipase | ACAAGTCTCTGAATAAGAAGT [C/G]AGGCTGGTGAGCATTCTGGG | ||
Hormone sensitive lipase | rs10422283 | 43 | 26 | T | C | 0.30 | LIPE | lipase, hormone-sensitive | GGAAGGAACCTCGTACATCCT [A/G]CGGGGCAGTGGGGACAGCGT | |
Lysosomal acid lipase | rs1556478 | 35 | 28 | A | G | 0.40 | LIPA | lipase A, lysosomal acid, cholesterol esterase (Wolman disease) | CACGGAGACTTATGCACCAGA [A/G]TGAAATGCTGAGATGTTCTT | |
rs6586179 | 45 | 7 | T | C | 0.08 | LIPA | lipase A, lysosomal acid, cholesterol esterase (Wolman disease) | ACCCTGCATTCTGAGGGGTCT [A/G]GAGGGAAACTGACAGCTGTG | ||
Endothelial lipase | rs4245232 | 45 | 15 | A | C | 0.17 | LIPG | lipase, endothelial | TAAAAAACTAAAGCCCGCCTG [A/C]GTCTTGTTAATGAATGATAG | |
Gastric lipase | rs814628 | 45 | 9 | A | G | 0.10 | LIPF | lipase, gastric | ATCGACTTCATTGTAAAGAAA [A/G]CTGGACAGAAGCAGCTACAC | |
Glycogen Synthases | Glycogen Synthase 1 (muscle) | rs2287754 | 35 | 16 | A | G | 0.23 | GYS1 | glycogen synthase 1 (muscle) | CGGGAAGCTTGCAAGACGCTC [A/G]GCTTCCTATTGCAAGACCGC |
Glycogen Synthase 2 (hepatic) | rs1478290 | 59 | 29 | T | G | 0.25 | GYS2 | glycogen synthase 2 (liver) | AATGTGGCTGAAGCCAAAAGC [A/C]TAATGAATGAGGGGAAGCCT | |
rs1871143 | 40 | 23 | T | G | 0.29 | GYS2 | glycogen synthase 2 (liver) | AGCCAGGAGCTTTCCTGGGCG [A/C]TTTTTGTACAGGATCTCATT | ||
rs2306179 | 44 | 18 | A | G | 0.20 | GYS2 | glycogen synthase 2 (liver) | TTTCAGTAGGTTTGCAGGGAA [A/G]CCAACTCAAAGCTATATCTG | ||
Glycogen Synthase 3b | rs4688046 | 44 | 19 | T | C | 0.22 | GSK3B | glycogen synthase kinase 3 beta | TAGTAAACTATTTCTTCCCAT [A/G]GGAGAAGATGGATTCTTTTC | |
rs334555 | 43 | 7 | C | G | 0.08 | GSK3B | glycogen synthase kinase 3 beta | AATTATATCTTATTATTAAAA [C/G]TCTACCAACTCAAAGCTTCC | ||
HDL Homeostasis | CETP | rs711752 | 46 | 36 | A | G | 0.39 | CETP | cholesteryl ester transfer protein, plasma | TTCAAGGTCAAGTTCTTTGGT [A/G]AGAAGGTCCTAGCTGCATTG |
rs3764261 | 41 | 20 | T | G | 0.24 | CETP | cholesteryl ester transfer protein, plasma | AGTGAATGAGATAGCAGACAA [A/C]CCAGATGCCTACCGACAGGT | ||
rs5880 | 44 | 4 | C | G | 0.05 | CETP | cholesteryl ester transfer protein, plasma | GATATCGTGACTACCGTCCAG [C/G]CCTCCTATTCTAAGAAAAGC | ||
rs1532624 | 51 | 33 | T | G | 0.32 | CETP | cholesteryl ester transfer protein, plasma | TCTGCCCCTTTGGGCTGCAGC [A/C]TCACAAGCTGTGTGGCGTTG | ||
rs5883 | 56 | 8 | T | C | 0.07 | CETP | cholesteryl ester transfer protein, plasma | AGCTACCTTGGCCAGCGAGTG [A/G]AAGACTCGCTCAGAGAACCA | ||
APOA1 | rs5070 | 41 | 18 | A | G | 0.22 | APOA1 | apolipoprotein A-I | GCCACGGGGATTTAGGGAGAA [A/G]GCCCCCCGATGGTTGGCTCC | |
APOC3 | rs4520 | 38 | 23 | T | C | 0.30 | APOC3 | apolipoprotein C-III | CTTGGTGGCGTGCTTCATGTA [A/G]CCCTGCATGAAGCTGAGAAG | |
rs2071521 | 45 | 37 | T | C | 0.41 | APOC3 | apolipoprotein C-III | ACAGCTCCTGTTGCCATAGGA [A/G]GGAGCTGGGTGAGATACTAG | ||
Appetite Hormones | Galanin | rs694066 | 56 | 6 | A | G | 0.05 | GAL | galanin | TTCTAAGTCCTCTGCCATGCC [A/G]GGAAAGCCTGGGTGCACCCA |
Neuro-peptide Y | rs1468271 | 48 | 5 | A | G | 0.05 | NPY | neuropeptide Y | GACCCTGTAATTTTCAGAAAC [A/G]CACATAGGAGTGGGTGTCTG | |
Ghrelin Precursor | rs26312 | 63 | 14 | A | G | 0.11 | GHRL | ghrelin precursor | GCTGTTGCTGCTCTGGCCTCT [A/G]TGAGCCCCGGGAGTCCGCAG |