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Table 4 Results of the association test of each SNP against the phenotypic variation residual from the regression of covariates in Table 3. Results significant at alpha ā‰¤ 0.05 are indicated in bold. Also shown are the FDR corrected p-value, the degrees of freedom in the regression model, the regression coefficient indicating the size of the effect of the minor allele, and the minimum effect size for 80% power of detection, relative to the standard deviation.

From: Physiogenomic analysis of weight loss induced by dietary carbohydrate restriction

SNP

Gene

p-value

FDR

degf

coeff

power

SNP type

rs936960

LIPC

0.7354

0.8011

47

0.351

2.08

intron 1

rs417344

LIPC

0.1322

0.5433

48

1.175

1.57

~5.5 kb upstream from LIPC

rs6083

LIPC

0.6944

0.8011

37

-0.226

1.25

S215N

rs295

LPL

0.5519

0.7843

44

-0.526

1.49

intron 6

rs328

LPL

0.1973

0.5744

51

-1.330

1.76

exon 9, *474S

rs10422283

LIPE

0.1610

0.5433

41

0.916

1.24

intron 1

rs1556478

LIPA

0.7417

0.8011

33

0.228

1.29

intron 5

rs6586179

LIPA

0.2575

0.6321

43

-1.189

2.08

exon 1, R23G

rs4245232

LIPG

0.1561

0.5433

43

0.906

1.50

~1.5 kb upstream

rs814628

LIPF

0.0002

0.0059

43

-3.658

1.86

exon 4, Ala161>Thr

rs2287754

GYS1

0.6950

0.8011

33

-0.324

1.51

5' UTR

rs1478290

GYS2

0.4504

0.7843

57

-0.381

1.13

~3.5 Kb upstream

rs1871143

GYS2

0.5236

0.7843

38

-0.381

1.31

intron 11

rs2306179

GYS2

0.0068

0.0610

42

-1.717

1.40

intron 5

rs4688046

GSK3B

0.5148

0.7843

42

-0.382

1.37

intron 3

rs334555

GSK3B

0.4553

0.7843

41

0.925

2.09

intron 1

rs711752

CETP

0.2127

0.5744

44

0.677

1.13

intron 1

rs3764261

CETP

0.6900

0.8011

39

0.263

1.36

~2.6 kb upstream

rs5880

CETP

0.0782

0.4220

42

2.769

2.71

P390A

rs1532624

CETP

0.5299

0.7843

49

0.339

1.12

intron 7

rs5883

CETP

0.0018

0.0237

54

-2.854

1.94

exon 9, synonymous

rs5070

APOA1

0.4406

0.7843

39

-0.454

1.41

Intron

rs4520

APOC3

0.4275

0.7843

36

-0.497

1.32

G34G

rs2071521

APOC3

0.9176

0.9176

43

-0.053

1.13

Upstream

rs694066

GAL

0.0231

0.1557

54

2.105

2.22

intron 1

rs1468271

NPY

0.7401

0.8011

46

-0.378

2.43

intron 1

rs26312

GHRL

0.7832

0.8133

61

0.233

1.50

~1 kb upstream