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Table 1 Binding kinetics for anti-human TC mAbs as measured by SPR

From: Characterization of a monoclonal antibody with specificity for holo-transcobalamin

MAb Isotype Epitope1 KD2 (nmol/L) Holo/apo specificity (-fold)
3–9 IgG1 1 0.03 1
3–11 IgG2a 2a 0.2 1
TC7 IgG2a 2a 10 1
4–7 IgG2b 2b 0.5 3
5H2 IgG1 2b >100 4
TC4 IgG1 3 5–10 1
TC2 IgG1 4 1 1
3C12 IgG1 5 5 1
3C4 IgG1 6 none >100
  1. 1 Epitope nomenclature follows that given in ref. 15. Mab 3C4 was originally assigned the same epitope as TC2 (epitope 4). Based on additional data, it has been reassigned a new epitope 6.
  2. 2 Approximate KD values for apoTC.