Table 1 Binding kinetics for anti-human TC mAbs as measured by SPR
From: Characterization of a monoclonal antibody with specificity for holo-transcobalamin
MAb | Isotype | Epitope1 | KD2 (nmol/L) | Holo/apo specificity (-fold) |
|---|---|---|---|---|
3–9 | IgG1 | 1 | 0.03 | 1 |
3–11 | IgG2a | 2a | 0.2 | 1 |
TC7 | IgG2a | 2a | 10 | 1 |
4–7 | IgG2b | 2b | 0.5 | 3 |
5H2 | IgG1 | 2b | >100 | 4 |
TC4 | IgG1 | 3 | 5–10 | 1 |
TC2 | IgG1 | 4 | 1 | 1 |
3C12 | IgG1 | 5 | 5 | 1 |
3C4 | IgG1 | 6 | none | >100 |