WB0 | WB5 | WB10 | WB20 | ||
---|---|---|---|---|---|
10 subjects with 2 – 4 repeated tests of each dose | n1 | 2.0 | 2.3 | 2.4 | 2.3 |
AUC2 | 9.2 ± 6.1 | 21.7 ± 12.4 | 42.5 ± 16.7 | 87.9 ± 34.6 | |
CV3 | 85 ± 56% | 73 ± 35% | 48 ± 35% | 35 ± 23% | |
9 subjects with 3 – 6 repeated tests of each dose | n | 3.7 | 3.6 | 3.8 | 3.7 |
AUC | 11.8 ± 10.3 | 27.6 ± 14.9 | 49.0 ± 21.6 | 90.6 ± 27.5 | |
CV | 103 ± 44% | 59 ± 16% | 44 ± 20% | 30 ± 11% | |
9 subjects with 4 – 7 repeated tests of each dose | n | 5.1 | 4.6 | 5.3 | 5.2 |
AUC | 8.1 ± 6.4 | 37.3 ± 22.6 | 65.7 ± 16.2 | 115.0 ± 27.3 | |
CV | 95 ± 53% | 62 ± 19% | 30 ± 15% | 26 ± 13% | |
All 28 Subjects | CV | 94 ± 50%a | 65 ± 25%b | 41 ± 26%c | 31 ± 16%c |