Figure 2

Glucose stimulated insulin release in UCP2 KO (A) and WT (B) islets. In UCP2 KO and WT islets, insulin secretion was measured in response to different concentrations of glucose in islets transfected with siPPARα (open squares, n = 5–6) or siC (closed squares, n = 8–9). *p < 0.05, **p < 0.01, ***p < 0.001 comparing response to glucose in siPPARα vs siC islets.