The rate of palmitate oxidation is shown in (μmol/kg/min), percent uptake oxidation and whole body palmitate release (μmol/kg/min). * indicates a change from pre to post treatment, and † represents a change from basal to clamp. Of interest was a significant increases in the rate of palmitate oxidation in the basal (P = 0.004) and clamp (P = 0.03) states following fenofibrate treatment, and the percent uptake oxidized (P = 0.04) Protein Kinase-C β membrane translocation is shown in relative units, representing activation in both the basal and the clamp hyper-insulinemic state following fenofibrate treatment. Protein Kinase-C θ membrane translocation, representing activation representing activation in both the basal and the clamp hyper-insulinemic state following fenofibrate treatment. * The activation of PKC-θ decreased significantly during hyper-insulinemia following fenofibrate treatment (P = 0.004).