| | PLA | FEN |
|---|
Measurement | Pre | Post | Pre | Post |
|---|
Palmitate oxidation
| | | | |
Basal | 0.85 ± 0.19 | 1.03 ± 0.12 | 0.99 ± 0.13 | 1.40 ± 0.13* |
Clamp | 0.32 ± 0.05† | 0.44 ± 0.04†* | 0.35 ± 0.05† | 0.74 ± 0.13†* |
Percent uptake oxidized
| | | | |
Basal | 28 ± 3 | 28 ± 3 | 24 ± 2 | 30 ± 2* |
Clamp | 27 ± 3 | 28 ± 1 | 27 ± 3 | 37 ± 5 |
Palmitate Release
| | | | |
Basal | 2.96 ± 0.5 | 3.66 ± 0.3 | 4.06 ± 0.4 | 4.7 ± 0.3 |
Clamp | 1.20 ± 0.2† | 1.94 ± 0.2† | 1.15 ± 0.2† | 2.04 ± 0.3† |
PKC-β
| | | | |
Basal | 0.35 ± 0.10 | 0.30 ± 0.11 | 0.25 ± 0.04 | 0.70 ± 0.25 |
Clamp | 1.12 ± 0.60 | 1.64 ± 0.70 | 1.99 ± 0.58 | 1.64 ± 0.46 |
PKC-θ
| | | | |
Basal | 1.38 ± 0.27 | 1.15 ± 0.36 | 0.87 ± 0.28 | 1.26 ± 0.38 |
Clamp | 0.98 ± 0.17 | 1.15 ± 0.48 | 0.87 ± 0.31 | 0.33 ± 0.11* |
- The rate of palmitate oxidation is shown in (μmol/kg/min), percent uptake oxidation and whole body palmitate release (μmol/kg/min). * indicates a change from pre to post treatment, and † represents a change from basal to clamp. Of interest was a significant increases in the rate of palmitate oxidation in the basal (P = 0.004) and clamp (P = 0.03) states following fenofibrate treatment, and the percent uptake oxidized (P = 0.04) Protein Kinase-C β membrane translocation is shown in relative units, representing activation in both the basal and the clamp hyper-insulinemic state following fenofibrate treatment. Protein Kinase-C θ membrane translocation, representing activation representing activation in both the basal and the clamp hyper-insulinemic state following fenofibrate treatment. * The activation of PKC-θ decreased significantly during hyper-insulinemia following fenofibrate treatment (P = 0.004).
