Plasma PLTP activity is inversely associated with HDL-C levels

Nutrition & Metabolism

Table 2 Univariate and multivariate estimates of PLTP activity levels.

Variable	Unadjusted estimated PLTP^† activity (Mean ± SE)	p-value	Adjusted* estimated PLTP^† activity (Mean ± SE)	p-value
Gender
Male	21.20 ± 1.03	0.03	24.15 ± 1.06	0.52
Female	18.27 ± 1.06		23.01 ± 1.08
Diabetes
Present	22.66 ± 1.06	0.08	24.38 ± 1.07	0.35
Absent	20.05 ± 1.03		22.80 ± 1.05
Hypertension
Present	20.13 ± 1.04	0.36	22.86 ± 1.05	0.27
Absent	21.21 ± 1.05		24.38 ± 1.06
Smoking
Smoker	21.58 ± 1.04	0.09	24.04 ± 1.07	0.52
Nonsmoker	21.58 ± 1.04		23.12 ± 1.05
CHD ^‡
Present	20.70 ± 1.03	0.68	23.50 ± 1.05	0.93
Absent	20.21 ± 1.05		23.66 ± 1.07
Low HDL-C ^§
Present	27.20 ± 1.05	<0.01	28.18 ± 1.06	<0.01
Absent	18.46 ± 1.03		19.77 ± 1.05
PLTP Polymorphism Type
gg	19.41 ± 1.04	0.03	21.18 ± 1.05	0.03
cg	21.26 ± 1.04		23.50 ± 1.06
cc	23.59 ± 1.09		26.36 ± 1.09

* Covariates appearing in the multivariate model were evaluated at values of age = 62.43 years and BMI = 25.21 kg/m²; † PLTP= Phospholipid transfer protein; ‡ CHD = Coronary Heart Disease with ≥50% coronary artery stenosis; § Low HDL-C defined as HDL-cholesterol level <0.8 mmol/L.

ISSN: 1743-7075