Figure 2

Plasma glucose (A), triglyceride (B), TNF-α (C), INF-γ (D), leptin (E), and total bile acid (F) concentrations in the OLETF and LETO rats fed the standard and high fat diets. Glucose and triglyceride concentrations in the plasma collected from the tail vein at 2, 8, and 15 weeks after the start of feeding the experimental diets were measured. TNF-α, INF-γ, leptin, and total bile acid concentrations in the plasma collected at the end of the experiment (at 16 weeks) were measured. Each value represents mean ± SEM, n = 9. Means without a common letter differ, P < 0.05. P values estimated by repeated measure 2 way ANOVA and 2-way ANOVA were (A) < 0.01 for strain, < 0.01 for diet, < 0.01 for time, 0.24 for strain x diet, < 0.01 for strain x time, < 0.02 for diet x time, and 0.07 for strain x diet x time, (B) < 0.01 for strain, < 0.01 for diet, < 0.01 for time, 0.02 for strain x diet, < 0.01 for strain x time, < 0.07 for diet x time, and 0.23 for strain x diet x time, (C) < 0.01 for strain, <0.03 for diet, and 0.06 for strain x diet, (D) < 0.01 for strain, <0.72 for diet, and 0.86 for strain x diet, (E) < 0.01 for strain, 0.01 for diet, and 0.82 for strain x diet, and (F) 0.10 for strain, <0.01 for diet, and 0.20 for strain x diet.