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Table 2 Body and organ weights, random blood glucose and plasma lipids for 7 and 11 mo old male Nile rats fed chow (#5020) with different onset to diabetes (Expt 4)

From: Nutritional correlates and dynamics of diabetes in the Nile rat (Arvicanthis niloticus): a novel model for diet-induced type 2 diabetes and the metabolic syndrome

 

7 mo

11 mo

 

Non-diabetic

Diabetic

Non-diabetic

Diabetic

 

R. blood gluc <150 mg/dL

R. blood gluc >150 mg/dL

R. blood gluc <150 mg/dL

R. blood gluc >150 mg/dL

 

n = 5

n = 5

n = 3

n = 7

Body weight, terminal (g)

112 ± 7

127 ± 13*

126 ± 10

124 ± 13

Food intake last mo (kcal/d)

NA

NA

37 ± 3

76 ± 15*

Water intake last mo (mL/d)

NA

NA

10 ± 2

72+8*

Blood glucose (mg/dL)

    

   Random

75 ± 43

266 ± 81*

98 ± 43

448 ± 39*†

   15 h fasting

43 ± 15

67 ± 25

79 ± 64

210 ± 99†

Organ weight (%BW)

    

   Liver

2.85 ± 0.32

4.35 ± 1.02*

2.66 ± 0.34

6.70 ± 0.62*†

   Kidney

0.77 ± 0.15

1.00 ± 0.21

0.82 ± 0.13

1.37 ± 0.26*

   Adipose

    

Perirenal

1.66 ± 0.66

2.28 ± 0.53

2.00 ± 0.91

0.68 ± 0.22*†

Epididymal

4.12 ± 0.71

2.88 ± 0.74

3.23 ± 0.70

2.53 ± 1.01

Suprascapular (brown fat)

1.90 ± 0.48

2.02 ± 0.37

1.97 ± 0.20

1.44 ± 0.73

Total fat (all above)

7.68 ± 1.31

7.18 ± 1.31

7.20 ± 1.61

4.64 ± 1.36†

Plasma

    

TC (mg/dL)

141 ± 21

173 ± 43

122 ± 26

391 ± 140*†

TG (mg/dL)

49 ± 16

124 ± 86

70 ± 16

659 ± 626

  1. Values are mean ± SD, total n = 20, NA = not available
  2. * Significant difference between non-diabetic and diabetic rats at 7 mo. (p < 0.05)
  3. † Significant difference between 7 and 11 mo, (p < 0.05)