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Table 2 Body and organ weights, random blood glucose and plasma lipids for 7 and 11 mo old male Nile rats fed chow (#5020) with different onset to diabetes (Expt 4)

From: Nutritional correlates and dynamics of diabetes in the Nile rat (Arvicanthis niloticus): a novel model for diet-induced type 2 diabetes and the metabolic syndrome

  7 mo 11 mo
  Non-diabetic Diabetic Non-diabetic Diabetic
  R. blood gluc <150 mg/dL R. blood gluc >150 mg/dL R. blood gluc <150 mg/dL R. blood gluc >150 mg/dL
  n = 5 n = 5 n = 3 n = 7
Body weight, terminal (g) 112 ± 7 127 ± 13* 126 ± 10 124 ± 13
Food intake last mo (kcal/d) NA NA 37 ± 3 76 ± 15*
Water intake last mo (mL/d) NA NA 10 ± 2 72+8*
Blood glucose (mg/dL)     
   Random 75 ± 43 266 ± 81* 98 ± 43 448 ± 39*†
   15 h fasting 43 ± 15 67 ± 25 79 ± 64 210 ± 99†
Organ weight (%BW)     
   Liver 2.85 ± 0.32 4.35 ± 1.02* 2.66 ± 0.34 6.70 ± 0.62*†
   Kidney 0.77 ± 0.15 1.00 ± 0.21 0.82 ± 0.13 1.37 ± 0.26*
   Adipose     
Perirenal 1.66 ± 0.66 2.28 ± 0.53 2.00 ± 0.91 0.68 ± 0.22*†
Epididymal 4.12 ± 0.71 2.88 ± 0.74 3.23 ± 0.70 2.53 ± 1.01
Suprascapular (brown fat) 1.90 ± 0.48 2.02 ± 0.37 1.97 ± 0.20 1.44 ± 0.73
Total fat (all above) 7.68 ± 1.31 7.18 ± 1.31 7.20 ± 1.61 4.64 ± 1.36†
Plasma     
TC (mg/dL) 141 ± 21 173 ± 43 122 ± 26 391 ± 140*†
TG (mg/dL) 49 ± 16 124 ± 86 70 ± 16 659 ± 626
  1. Values are mean ± SD, total n = 20, NA = not available
  2. * Significant difference between non-diabetic and diabetic rats at 7 mo. (p < 0.05)
  3. † Significant difference between 7 and 11 mo, (p < 0.05)