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Table 3 Crossectional comparison in male Nile rats separated between 4 and 9 wks and fed high-fat, low-fiber Western-typediet for 2 to 12 wks to assess stages of insulin resistance (Expt 5)

From: Nutritional correlates and dynamics of diabetes in the Nile rat (Arvicanthis niloticus): a novel model for diet-induced type 2 diabetes and the metabolic syndrome

 

Stages

 

A

B

C

D

Age at separation

    

4-5 wks (followed for 2 wks)

    

BW (g)

70 ± 11a,b

79 ± 9a

83 ± 13b

 

n = 36

13 (36%)

18 (50%)

5 (14%)

0

Insulin (ng/mL)

1.0 ± 0.8a,b

7.7 ± 3.1a

6.3 ± 1.7b

 

Random blood glucose (mg/dL)

72 ± 33a

77 ± 33b

223 ± 65a,b

 

TG (mg/dL)

53 ± 23a

69 ± 21b

145 ± 75a,b

 

TC (mg/dL)

91 ± 33

96 ± 19

105 ± 33

 

Age at separation

    

6-7 wks (followed for 4 wks)

    

BW (g)

89 ± 10a,b

101 ± 11a

103 ± 12b

 

n = 27

11 (41%)

11 (41%)

5 (19%)

0

Insulin (ng/mL)

1.9 ± 1.1a

6.8 ± 2.2a

5.4 ± 3.8

 

Random blood glucose (mg/dL)

44 ± 12a

59 ± 25b

341 ± 154a,b

 

TG (mg/dL)

37 ± 10a

50 ± 21b

286 ± 129a,b

 

TC (mg/dL)

57 ± 11a

80 ± 15b

117 ± 72a,b

 

Age at separation

    

8-9 wks (followed for 12 wks)

    

BW (g)

101 ± 14a,b

120 ± 7

126 ± 14a

133 ± 23b

n = 20

3 (15%)

6 (30%)

8 (40%)

3 (15%)

Insulin (ng/mL)

1.4 ± 0.4a,b

7.4 ± 2.1a,c

9.0 ± 4.3b,d

1.7 ± 0.9c,d

Random blood glucose (mg/dL)

62 ± 17a,b

70 ± 6c,d

340 ± 165a,c,e

534 ± 72b,d,e

TG (mg/dL)

55 ± 16a

66 ± 7b

192 ± 141a,b

132 ± 26

TC (mg/dL)

129 ± 16

111 ± 19

172 ± 108

176 ± 25

  1. Values are mean ± SD
  2. a,b,c,d,e Means in row sharing a common superscript are significantly different (P < 0.05) using one-way ANOVA and Fischer's PLSD test.
  3. Stage A = normal, Stage B = elvevated insulin, Stage C = elevated insulin and glucose, Stage D = declining insulin, elevated glucose
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Nutrition & Metabolism

ISSN: 1743-7075

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