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Table 3 Crossectional comparison in male Nile rats separated between 4 and 9 wks and fed high-fat, low-fiber Western-typediet for 2 to 12 wks to assess stages of insulin resistance (Expt 5)

From: Nutritional correlates and dynamics of diabetes in the Nile rat (Arvicanthis niloticus): a novel model for diet-induced type 2 diabetes and the metabolic syndrome

  Stages
  A B C D
Age at separation     
4-5 wks (followed for 2 wks)     
BW (g) 70 ± 11a,b 79 ± 9a 83 ± 13b  
n = 36 13 (36%) 18 (50%) 5 (14%) 0
Insulin (ng/mL) 1.0 ± 0.8a,b 7.7 ± 3.1a 6.3 ± 1.7b  
Random blood glucose (mg/dL) 72 ± 33a 77 ± 33b 223 ± 65a,b  
TG (mg/dL) 53 ± 23a 69 ± 21b 145 ± 75a,b  
TC (mg/dL) 91 ± 33 96 ± 19 105 ± 33  
Age at separation     
6-7 wks (followed for 4 wks)     
BW (g) 89 ± 10a,b 101 ± 11a 103 ± 12b  
n = 27 11 (41%) 11 (41%) 5 (19%) 0
Insulin (ng/mL) 1.9 ± 1.1a 6.8 ± 2.2a 5.4 ± 3.8  
Random blood glucose (mg/dL) 44 ± 12a 59 ± 25b 341 ± 154a,b  
TG (mg/dL) 37 ± 10a 50 ± 21b 286 ± 129a,b  
TC (mg/dL) 57 ± 11a 80 ± 15b 117 ± 72a,b  
Age at separation     
8-9 wks (followed for 12 wks)     
BW (g) 101 ± 14a,b 120 ± 7 126 ± 14a 133 ± 23b
n = 20 3 (15%) 6 (30%) 8 (40%) 3 (15%)
Insulin (ng/mL) 1.4 ± 0.4a,b 7.4 ± 2.1a,c 9.0 ± 4.3b,d 1.7 ± 0.9c,d
Random blood glucose (mg/dL) 62 ± 17a,b 70 ± 6c,d 340 ± 165a,c,e 534 ± 72b,d,e
TG (mg/dL) 55 ± 16a 66 ± 7b 192 ± 141a,b 132 ± 26
TC (mg/dL) 129 ± 16 111 ± 19 172 ± 108 176 ± 25
  1. Values are mean ± SD
  2. a,b,c,d,e Means in row sharing a common superscript are significantly different (P < 0.05) using one-way ANOVA and Fischer's PLSD test.
  3. Stage A = normal, Stage B = elvevated insulin, Stage C = elevated insulin and glucose, Stage D = declining insulin, elevated glucose