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Table 4 Body and organ weights, blood glucose, fasting insulin and plasma lipids for 5-wk old male Nile rats with early- or late-onset diabetes when fed a high-fat, low-fiber purified diet for 4 wks (Expt 6)

From: Nutritional correlates and dynamics of diabetes in the Nile rat (Arvicanthis niloticus): a novel model for diet-induced type 2 diabetes and the metabolic syndrome

 

High-fat, low-fiber diet (Western-type)

 

Early-onset

Late-onset

Body weight (g)

  

   Initial (age: 5 wks)

62 ± 6

61 ± 4

   After 2 wks

90 ± 6

79 ± 7*

   After 4 wks

104 ± 6

90 ± 8*

Body weight gain (wks 5-7) (g/d)

2.2 ± 0.1

1.3 ± 0.4*

Food Intake (wks 5-7) (g/d)

14.8 ± 0.6

12.3 ± 0.9*

   (kcal/d)

40.5 ± 1.7

33.8 ± 2.8*

Growth efficiency (kcal/d/g BW gain)

18.5 ± 1.1

28.2 ± 7.1*

Water Intake (wks 5-7) (mL/d)

15 ± 6

9 ± 5

Random blood glucose (mg/dL)

  

   Initial (age: 5 wks)

110 ± 55

79 ± 18

   After 4 wk

344 ± 80

46 ± 10*

Organ weight (%BW)

  

   Liver

3.87 ± 0.84

3.22 ± 0.42

   Kidney

0.73 ± 0.11

0.70 ± 0.13

   Adipose

  

Perirenal¥

2.65 ± 0.33

1.82 ± 0.76*

Epididymal

5.40 ± 0.57

3.80 ± 0.98*

Omental

2.61 ± 0.38

2.05 ± 0.59

Inguinal

1.64 ± 0.20

1.39 ± 0.42

Suprascapular (brown fat)

2.18 ± 0.16

1.52 ± 0.49

Total fat (all above)

14.5 ± 1.5

10.6 ± 2.8*

   Carcass

67.2 ± 0.9

72.8 ± 2.2*

Body length (cm)

13.4 ± 0.2

12.6 ± 0.5*

BMI (kg/m2)

5.8 ± 0.4

5.5 ± 0.2

LMI (Carcass wt kg/m2)

3.9 ± 0.2

4.0 ± 0.1

Plasma

  

   TC (mg/dL)

88 ± 26

63 ± 4

   TG (mg/dL)

126 ± 14

96 ± 19*

   Insulin (ng/mL)

18.2 ± 3.4

5.3 ± 3.2*

   HbA1c (%)

6.5 ± 0.7

5.3 ± 0.4*

  1. Values are mean ± SD (n = 4)
  2. * Significantly different (P < 0.05)
  3. ¥ Represents perirenal + retroperitoneal fat pad.