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Table 4 Body and organ weights, blood glucose, fasting insulin and plasma lipids for 5-wk old male Nile rats with early- or late-onset diabetes when fed a high-fat, low-fiber purified diet for 4 wks (Expt 6)

From: Nutritional correlates and dynamics of diabetes in the Nile rat (Arvicanthis niloticus): a novel model for diet-induced type 2 diabetes and the metabolic syndrome

  High-fat, low-fiber diet (Western-type)
  Early-onset Late-onset
Body weight (g)   
   Initial (age: 5 wks) 62 ± 6 61 ± 4
   After 2 wks 90 ± 6 79 ± 7*
   After 4 wks 104 ± 6 90 ± 8*
Body weight gain (wks 5-7) (g/d) 2.2 ± 0.1 1.3 ± 0.4*
Food Intake (wks 5-7) (g/d) 14.8 ± 0.6 12.3 ± 0.9*
   (kcal/d) 40.5 ± 1.7 33.8 ± 2.8*
Growth efficiency (kcal/d/g BW gain) 18.5 ± 1.1 28.2 ± 7.1*
Water Intake (wks 5-7) (mL/d) 15 ± 6 9 ± 5
Random blood glucose (mg/dL)   
   Initial (age: 5 wks) 110 ± 55 79 ± 18
   After 4 wk 344 ± 80 46 ± 10*
Organ weight (%BW)   
   Liver 3.87 ± 0.84 3.22 ± 0.42
   Kidney 0.73 ± 0.11 0.70 ± 0.13
   Adipose   
Perirenal¥ 2.65 ± 0.33 1.82 ± 0.76*
Epididymal 5.40 ± 0.57 3.80 ± 0.98*
Omental 2.61 ± 0.38 2.05 ± 0.59
Inguinal 1.64 ± 0.20 1.39 ± 0.42
Suprascapular (brown fat) 2.18 ± 0.16 1.52 ± 0.49
Total fat (all above) 14.5 ± 1.5 10.6 ± 2.8*
   Carcass 67.2 ± 0.9 72.8 ± 2.2*
Body length (cm) 13.4 ± 0.2 12.6 ± 0.5*
BMI (kg/m2) 5.8 ± 0.4 5.5 ± 0.2
LMI (Carcass wt kg/m2) 3.9 ± 0.2 4.0 ± 0.1
Plasma   
   TC (mg/dL) 88 ± 26 63 ± 4
   TG (mg/dL) 126 ± 14 96 ± 19*
   Insulin (ng/mL) 18.2 ± 3.4 5.3 ± 3.2*
   HbA1c (%) 6.5 ± 0.7 5.3 ± 0.4*
  1. Values are mean ± SD (n = 4)
  2. * Significantly different (P < 0.05)
  3. ¥ Represents perirenal + retroperitoneal fat pad.